This essay employs reflective practice to explore safe medication management during the transition to clinical nursing practice. It addresses challenges related to prioritizing patient care, medication management, intervention planning, time management, and decision-making. The discussion incorporates regulatory frameworks and governance underpinning the nursing profession, drawing on personal placement experiences and relevant research to devise strategies for a healthy transition as a graduate nurse. The essay highlights the importance of safe medication practices, guided by the Australian Commission on Safety and Quality in Healthcare guidelines and National Safety and Quality in Health Service Standards. It reflects on incidents involving potential medication errors, such as confusing look-alike, sound-alike (LASA) drugs and incorrect dosage administration, and proposes strategies like using Tall Man lettering and thorough medication reviews to enhance practice and ensure patient safety. The essay further emphasizes the role of clinical handovers, interdisciplinary coordination, and adherence to ethical codes and professional conduct standards in delivering safe and effective patient care.