This report provides a detailed case study analysis of the system science and engineering principles applied to the design and construction of four iconic skyscrapers: the Empire State Building, One World Trade Center, Shanghai Tower, and Burj Khalifa. The report begins with an executive summary and table of contents, followed by an introduction to the key concepts. It then delves into the stakeholder needs, conceptual design process, and system requirements for each building, including business needs, stakeholder requirements, system level synthesis, and system design reviews. The report highlights the multidisciplinary fields involved, such as communication, electrical, hydraulic, mechanical, and civil engineering, and examines the use of building information modeling. The analysis explores the specific design challenges and innovative solutions implemented in each skyscraper, such as wind load reduction, material efficiency, and sustainable design features. The report concludes with a summary of findings and references to the sources used. This assignment explores the key factors that contribute to the success of these architectural marvels, offering valuable insights into the complex engineering and design processes involved in creating some of the world's tallest buildings.