This essay delves into the multifaceted realm of contemporary public health issues, with a specific focus on their influence on mortality rates within Australia. It begins by defining mortality rates and highlighting their dynamic nature, influenced by a range of social, economic, and environmental factors. The essay then meticulously examines the social determinants of health, including race/ethnicity, infectious diseases, biological factors, income levels, globalization, social injustice, behavioral and psychosocial elements. Simultaneously, it explores environmental determinants, such as exposure to toxic substances, cigarette consumption, and air and water pollution, and their respective impacts on mortality. The analysis further extends to the effects of globalization, infectious diseases like HIV/AIDS, income disparities, biological factors like sex differences, education, and social injustice. The essay underscores the necessity for public health practitioners and governmental bodies to collaborate in implementing effective strategies, policies, and indicators to monitor and mitigate the impacts of these factors, ultimately working towards reducing mortality rates and improving overall public health outcomes in Australia. The essay emphasizes the role of organizations like the World Health Organization (WHO) and the importance of applying health indicators to understand and address the fluctuating nature of mortality.