Annotated Bibliography: Stem Cell Therapy and Alzheimer's Research

This annotated bibliography provides a compilation of research articles focusing on the application of stem cell therapies in the treatment of Alzheimer's disease. The included studies investigate various aspects of stem cell transplantation, including the use of human umbilical cord mesenchymal stem cells, bone marrow-derived mesenchymal stem cells, and neural stem cells. These studies explore the potential of stem cells to improve cognitive function, reduce oxidative stress, promote neurogenesis, and alleviate Alzheimer's-like pathology in both in vitro and in vivo models. The bibliography covers a range of approaches, such as intravenous transplantation, stereotactic brain injection, and the use of exosomes derived from stem cells, to address the complex mechanisms underlying Alzheimer's disease.

Running Head: ANNOTATED BIBLIOGRAPHY
Annotated Bibliography
Students Name
University Affiliation
Date

ANNOTATED BIBLIOGRAPHY 2
Annotated Bibliography
References
Cui, Y, Ma, S, Zhang, C, Cao, W, Liu, M, Li, D, Lv, P, Xing, Q, Qu, R, Yao, N, Yang, B &
Guan, F 2017, ‘Human umbilical cord mesenchymal stem cells transplantation improves
cognitive function in Alzheimer’s disease mice by decreasing oxidative stress and promoting
hippocampal neurogenesis’, Behavioral Brain Research, vol. 320, pp. 291–301
Esmaeilzade, B, Artimani, T, Amiri, I, Najafi, R, Shahidi, S, Sabec, M, Farzadinia, P, Zare, M,
Zahiri, M & Soleimani Asl, S 2019, ‘Dimethyloxalylglycine preconditioning enhances protective
effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer
disease’, Physiology & Behavior, vol. 199, pp. 265–272
Haiyan, H, Rensong, Y, Guoqin, J, Xueli, Z, Huaying, X & Yanwu, X 2016, Effect of
Astragaloside IV on neural stem cell transplantation in Alzheimer’s disease rat models.
Evidence-Based Complementary and Alternative Medicine, vol. 2016, no. 6, pp. 1–8.
Hoveizi, E, Mohammadi, T, Moazedi, AA, Zamani, N & Eskandary, A 2018, ‘Transplanted
neural-like cells improve memory and Alzheimer-like pathology in a rat model’, Cytotherapy
(Elsevier Inc.), vol. 20, no. 7, pp. 964–973
Kanamaru, T, Kamimura, N, Yokota, T, Nishimaki, K, Iuchi, K, Lee, H et al. 2015, Intravenous
transplantation of bone marrow-derived mononuclear cells prevents memory impairment in
transgenic mouse models of Alzheimer’s disease. Brain Research, vol. 1605, pp. 49-58.
Kim, HJ, Seo, SW, Chang, JW, Lee, JI, Kim, CH, Chin, J et al. 2015, Stereotactic brain
injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's

ANNOTATED BIBLIOGRAPHY 3
disease dementia: a phase 1 clinical trial. Alzheimer's & Dementia: Translational Research &
Clinical Interventions, vol. 1, no. 2, pp. 95-102.
Lee, M, Ban, J-J, Yang, S, Im, W & Kim, M 2018, ‘The exosome of adipose-derived stem cells
reduces β-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse
model of Alzheimer’s disease’, Brain Research, vol. 1691, pp. 87–93
McGinley, LM, Kashlan, ON, Bruno, ES, Chen, KS, Hayes, JM, Kashlan, SR et al. 2018,
Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s
disease. Scientific Reports, vol. 8, no. 1, pp. 14776.
Oh, S, Son, M, Choi, J, Lee, S & Byun, K 2018, ‘sRAGE prolonged stem cell survival and
suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer’s
disease model’, Biochemical & Biophysical Research Communications, vol. 495, no. 1, pp. 807–
813
Young, JE, Fong, LK, Frankowski, H, Petsko, GA, Small, SA and Goldstein, LS 2018,
Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces
TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem Cell Reports, vol. 10,
no. 3, pp. 1046-1058