This report provides a comprehensive overview of harm reduction strategies against substance abuse, detailing the role of Licensed Practical Nurses (LPNs) in implementing these strategies, including screening, emotional support, education, and resource provision. It identifies key players such as the government, healthcare management, and NGOs, and discusses their respective roles in strategy implementation. The report also emphasizes ethical considerations like beneficence, nonmaleficence, and respect for autonomy, highlighting the importance of building therapeutic relationships and providing compassionate care. Additionally, it addresses cultural considerations, emphasizing the need for culturally sensitive approaches to address the underlying causes of substance abuse and create a welcoming environment for individuals. The report references multiple sources to support its findings and recommendations.