This report presents a systematic review of 12 peer-reviewed articles to assess the impact of 12-hour working shifts on nurses' health, performance, and job satisfaction. The study investigates the causes of the increasing prevalence of these shifts, their influence on working efficiency and well-being, and the effects of prolonged work durations on fatigue and work-life balance. The research employs a post-positivism approach and secondary study methods, using databases such as NCBI, ProQuest, Medline, CINAHL, and SCOPUS. Findings indicate that rotational shift work increases the risk of coronary heart diseases, occupational stress affects nursing efficacy, and prolonged work has a detrimental impact on physical health. Night shifts also negatively affect working efficiency and increase BMI levels. The conclusion highlights the negative consequences of long working hours and rotational duties on nurses' emotional well-being and working efficiency. The report includes an introduction, background, research questions, aim and objectives, rationale, search strategy, philosophical worldviews, research design, approach, and methods, followed by a discussion of evidence, findings, analysis, implications, limitations, and conclusion. The appendices include a PRISMA flow diagram.