This report presents a bioengineering and occupational study focusing on the health effects of rotenone pesticide exposure. It identifies occupational health as a critical area, emphasizing the dangers of chemical exposure, specifically pesticides like rotenone. The study details the health and toxic effects of rotenone, including its flammability, reactivity, and potential for causing skin irritation, respiratory damage, and other adverse health outcomes through various routes of exposure, such as skin contact, inhalation, and ingestion. The report suggests in vitro models, particularly cell or tissue modeling, and in vivo models using live mice to study the mechanisms of toxicity and dose-response relationships. It proposes the development of a tissue model to simulate exposure and evaluate the effects at a cellular and tissue level, aiming to formulate effective remediation strategies against pesticide-related health damages. The conclusion underscores the responsibility of employers and employees in managing occupational risks and stresses the importance of establishing robust occupational health and safety management systems. The references provide a comprehensive list of sources used in the study.
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