This report offers a detailed clinical update on Tuberculosis, encompassing its etiology, pathogenesis, and global prevalence. It explores the causes of the disease, the role of Mycobacterium tuberculosis, and risk factors. The report delves into the diagnostic processes, including physical examinations, skin tests, and imaging techniques. It also examines both pharmacological and non-pharmacological treatment options, including the BCG vaccine and physiotherapy. Furthermore, the report highlights the implications for public health, emphasizing the importance of health promotion, awareness campaigns, and government health schemes. The report also covers the clinical manifestations of both latent and active tuberculosis, as well as the nursing practices involved in patient care. The report concludes by emphasizing the importance of early diagnosis, effective treatment, and public health initiatives to control the spread of the disease.