This literature review examines the management of indwelling urinary catheters, focusing on evidence-based guidelines to prevent catheter-associated urinary tract infections (CAUTIs). The review synthesizes findings from various studies, including those by Modey et al. (2015), Loveday et al. (2014), and Conway and Larson (2012), highlighting the importance of aseptic techniques, hand hygiene, and appropriate catheter use. It emphasizes the need for strict adherence to protocols, such as the use of catheter bundles, and the implementation of nurse-driven protocols to reduce CAUTI incidence. The review also discusses the significance of timely screening, antimicrobial stewardship, and the judicious use of indwelling catheters, advocating for their removal when no longer necessary. Furthermore, it underscores the importance of institutional policies, education of healthcare workers, and the use of closed drainage systems to minimize the risk of infection. The review concludes by stressing the need for further research to improve catheter management and prevent UTIs.