This case study focuses on Mr. Kirkman's urosepsis, detailing the pathogenesis of urinary tract infections leading to systemic inflammatory response syndrome. It explores the clinical manifestations, including symptoms like abdominal pain, dark urine, and low oxygen saturation, alongside laboratory findings such as elevated white blood cells, abnormal creatinine and urea levels, and electrolyte imbalances. The analysis delves into the body's immune response, the effects on various systems, and the role of lifestyle factors like smoking and drinking. The study highlights the importance of early administration of intravenous antibiotics and fluid resuscitation, along with ABG analysis to guide treatment. The discussion covers the causes of metabolic acidosis and the significance of base excess deficit, offering a comprehensive overview of urosepsis management and nursing strategies.