This case study examines a 75-year-old male, Mr. Kirkman, admitted to the emergency department with a urinary tract infection (UTI) that progressed to sepsis. It details the pathophysiology of UTI, including the ascending route of infection, bacterial colonization, and biofilm formation. The case study further explains how the infection led to pyelonephritis, urosepsis, and septic shock, resulting in symptoms such as high heart rate, hypotension, and elevated body temperature. Arterial blood gas results revealed metabolic acidosis, hypoxemia, and elevated lactate levels. The study concludes by outlining appropriate nursing strategies, including symptom evaluation, maintaining an acidic bladder environment, and increasing fluid intake to manage the patient's condition. The case highlights the importance of early diagnosis and intervention in preventing the progression of UTI to severe sepsis.