This report on global vaccinology examines the prevalent diseases affecting newborns, infants, and children, along with recommended vaccination and prevention strategies. It highlights tetanus in newborns and the use of the DTP, DT, and TT vaccines. For infants, the report discusses rotavirus, its impact, and the available vaccines like RotaTeq (RV5) and Rotarix (RV1). The report also addresses malaria and HIV in children, emphasizing prevention measures such as antimalarial drugs and pre-exposure prophylaxis for HIV. The report references several studies and guidelines from the World Health Organization and the CDC to support its findings. It provides a comprehensive overview of the current landscape of global vaccinology, focusing on the diseases, vaccines, and prevention strategies for these vulnerable groups.