This report provides an overview of vaccines and immunotherapy within the field of immunology. It begins by defining vaccination as a crucial method for protecting individuals from harmful diseases, emphasizing its role in providing active acquired immunity. The main body of the report then delves into the advantages and disadvantages of vaccines, highlighting their effectiveness in preventing diseases and achieving herd immunity, while also acknowledging potential side effects. The report further evaluates immunotherapy, detailing its mechanisms, benefits in enhancing the immune system, and its ability to improve the efficacy of other treatments. It also addresses the limitations and potential adverse reactions associated with immunotherapy. The conclusion summarizes the merits and demerits of both vaccines and immunotherapy, providing a balanced perspective on their roles in disease prevention and treatment.