Toxicology Assignment Solved
Added on 2021-04-17
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Running head: TOXICOLOGYToxicologyName of the StudentName of the UniversityAuthor Note
1TOXICOLOGYTable of ContentsIntroduction................................................................................................................................2Answer 1....................................................................................................................................2Cell culture or tissue culture..................................................................................................2Animal Model or Xenograft Model.......................................................................................3Computer Stimulations Model...............................................................................................3Answer 2....................................................................................................................................4Answer 3....................................................................................................................................4References..................................................................................................................................5
2TOXICOLOGYIntroductionAccording to the latest report published by University of Warwick in Chemie International Edition, a new drug derived from metal iridium is capable of manipulating the signaling pathways of the body. They named this drug ZL105 (Habtemariam et al., 2016). Primary data indicates that this novel drug is 10 times more active than other available anti-cancer drugs which are used for treating ovarian cancer, colon cancer, breast cancer, renal cancer and melanoma (Habtemariam et al., 2016).Answer 1Same drug will behave differently in relation to the surrounding host environment andhence modeling of the anti-cancerous drug is crucial in order check the efficacy of the drugs however, the entire process is extremely daunting and it is difficult to create host specific environment each time (). Some of the common methods, which are used for drug modeling, include cell or tissue culture technique, Animal or xenograft model and computer stimulation model. Cell culture or tissue cultureThe application of tumor cell lines helps the researchers to check the efficacy of the compounds in its highly reproducible form. A characterized cell line also ensures parallel screening assays where the effect of drug proliferation on multiple cell-lines can be effectively determined. For example: NCI-60 Human Tumor Cell Line is offered by the development therapeutics program of National Cancer Institute in order to check the efficacy of the drug (Abaan et al., 2013). However, cell line also has certain share of disadvantage likethey lack genotypic and phenotypic heterogeneity of neoplastic cells present in the tumors and are highly selective. Moreover, the differentiation of the cancer cell line in the cell culture medium at times results in the generation of genetic and epigenetic changes that
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