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Article On Acetylcholine by Otto Loewi

   

Added on  2020-02-24

3 Pages633 Words48 Views
Acetylcholine, which is the most widely known and spread neurotransmitter, was invented in 1914 by Hallett Dale and the existence later confirmed by Otto Loewi. Acetylcholineis a chemical message that aids in the transmission of signals throughout the nerve synapse and can be found both in the central nervous systems and the peripheral systems. Neurotransmitters are the known messengers of the brain and have their origin from within the body. They carry messages from a neuron to another. Cholinergic neurons are neurons which use acetylcholine in the transmission of signals and such neurons use synapses as the communication path[CITATION San15 \p 615 \l 1033 ]. Acetylcholine in the Peripheral nervous systemAcetylcholine acts as neurotransmitter found at the junction of the neuro muscles found between the skeletal muscles and the motor nerve. Here it acts as an effective stimulant of the movement of the muscles. The receptors of acetylcholine on the muscles accept acetylcholine thereby causing a contraction in the skeletal muscles. In the combination of acetylcholine receptors with acetylcholine, the gated ligand sodium fees found in the cell membrane is unlocked thereby resulting in the contraction of the skeletal muscles[CITATION Dav142 \p 715 \l 1033 ]. The unlocked sodium ions then move into the cell of the muscle triggering movements that end up generating tightening of the muscles. Acetylcholine receptors are also responsible forthe relaxation of the muscles of the heart[CITATION Knu13 \p 547 \l 1033 ]. In as much as acetylcholine triggering the tightening of skeletal muscles, its operation is through a diverse receptor form for example muscarinic thereby hampering the tightening of the strands of the
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