Pathophysiological Event in Atherosclerotic Plaque Formation

Assessment

TABLE OF CONTENTS
INTRODUCTION...........................................................................................................................3
Pathophysiological event that lead to atherosclerotic plaque formation in a coronary artery.....3
Comparison and contrasting stable and unstable angina in coronary heart disease....................3
Comparison of STEMI with NSTEMI.........................................................................................4
4 MOA of Tenecteplase...............................................................................................................4
REFERENCES................................................................................................................................6

Pathophysiological event that lead to atherosclerotic plaque formation in a coronary artery
In regard to proper functioning of body it can be said that there is requirement of
continuous supply of oxygen in heart and it can be done by coronary arteries. Margaret, 52 year
old woman facing problems like chest pain and it was causes of unhealthy diet that lead to
elevated blood cholesterol. In regard to atherosclerosis plaque formation it can be said that it
happens because of hypercholesterolaemia. Atherosclerosis that is also known as hardening of
the arteries that mainly happen when both cholesterol and calcium build up inside the lining of
the artery wall Asada & et.al., (2020). This substance that it forms is known as plaque. As per the
pathophysiological study, atherosclerosis can lead to endothelial injury. In regard to Margaret it
can be said that, this process or plaque formation started to build because of unhealthy diet
because heart requires blood and oxygen but due to oily and junk foods, cholesterol level
increases. It leads to lipid retention, oxidation as well as modification that blocks or provoke
chronic inflammation in the walls of arteries Peng & et.al., (2019) . So, it can easily be said that
due to increasing age, cholesterol level due to unhealthy diet, calcium started to collect in arteries
that build up a plaque and became reason of chest pain in Margaret.
Comparison and contrasting stable and unstable angina in coronary heart disease
Angina in simple term refers or known as chest pain. It may be stable and unstable.
Stable angina or chest pain occurs in people when they exert themselves physically and feel
stress. This angina or chest pain when it happens predictably then it does not worsen with time
and also does not change in frequency Cui & et.al., (2018). On the other hand, unstable angina or
chest pain happens when heart of people do not get enough blood flow as well as oxygen. It may
be severe and lead to heart attack. Similarity between both is as they both are considered as heart
attack.
The main difference between stable and unstable angina is, stable angina or chest pain
occur when people do physical activity, or they push themselves physically. It goes away when
they take rest and medications, Whereas, unstable chest pain occurs when people are on rest
mode or resting rather doing physical activity. So, from this difference it can easily be said that
unstable angina is critical or severer than stable because it happens due to blood clots or
blockage in arteries Eleonora & et.al., (2020).