Bacterial Meningitis: Risk Factors, Pathophysiology, Diagnostic Tests and Treatment

This presentation discusses the risk factors, pathophysiology, diagnostic tests and treatment options for bacterial meningitis. It explores the link between patient risk factors and etiology, and provides an overview of the diagnostic tests and treatment options available for this condition.

Immuno-compromised state
Person-to-person transmission
of bacterial infection
Poor
immunity
Entry and invasion of
pathogen (Haemophilus
influenza ) into subarachnoid
space
Pathophysiology
Risk Factors
Aetiology
Clinical
manifestations
Diagnostic tests
Treatment
Crowded
household,
poverty and
day care
attendance
No
vaccination
Bacterial
meningitis
Lumbar Puncture
Antibiotic therapy like
used cephalosporin and
tetracyclien
Transmission and spread of
pathogen
Activation of the immune
system
Cytokine production and
increase in white blood cells
Changes in CSF composition Edema
Frequent
infection
and short
duration of
breast
feeding
Supportive care like
oxygen therapy , blood
pressure management and
emergency management
of patient
To control symptom of
breathing problem and high
blood pressure in infant
Administration of
Influenza vaccine
Blood test
Neuronal damage and
inflammation
Reduce neonatal
sepsis
Key
Imaging test like MRI scan
Clinical manifestation of fever,
seizures , vomoting and stiff neck,

Link between patient risk factor and etiology:
Ethan is an 18 month-year-old boy who has been diagnosed with bacterial meningitis after presenting to the hospital with symptom of high fever over the last 24 hours.
Ethan was also found to have a passive resistance to passive neck flexion and high blood pressure. Bacterial meningitis is a clinical condition resulting in infection of membranes
surrounding the brain and the spinal cord. In case of Ethan, bacterial influenza was caused due to Haemophilus influenza. The risk for Hemophilus meningitis is understood from
vaccination history of a person as well as the vaccination history of the population group. This suggest links between herd immunity and risk of developing Hemophilus
meningitis. Ethan’s mother also admitted that he was not vaccinated since his birth (Townsend-Payne et al., 2016).
Apart from vaccination, many socioeconomic factors like day care attendance, presence of other sibling crowded household and poverty, poor nutrition also increases the
risk of developing Hemophilus meningitis. In case of Ethan, individual factors such as frequent infection and short duration of breast feeding might also be the risk factor for the
condition. The risk of developing the disease increases due to day care attendance because of contact with other children who may be carriers of the Haemophilus influenza
bacteria (Lundbo & Benfield, 2017). These risk factor has links with the pathophysiology of the bacterial meningitis as all the above risk factors increased the risk of transmission
of the bacteria through respiratory droplets. The bacteria may be present in the nose or through of a person and it may be transmitted while sneezing or coughing. In this way, by
means of person-to-person transmission, Haemophilus colonization occurs in a person and the capsule is the main factors that contribute to the virulence of the bacteria. The
type b form is the capsulated strain of the bacteria and this plays a role in systemic infection (King, 2012).
Pathophysiology of the condition:
The pathophysiology of bacterial meningitis can explain the reason behind presence of symptoms like high fever, vomiting, seizure, stiff neck and headache. Bacterial
meningitis is a condition that leads to inflammation of the meninges and the presence of edema is the reason for manifestation of symptoms like fever and seizure. The pathway
that leads to inflammation of the meninges is understood from the detailed pathophysiology of Haemophilus meningitis. The pathogen entry or invasion of subarachnoid spa
occurs due to person-to-person transmission and presence of risk factors like immune-compromised status of patient. The invasion of the pathogen into the bloodstream results
in host immune response and type b serotype is involved in contributing to invasiveness of the pathogen. After the activation of the immune system due to pathogen invasion,
cytokine, nitric oxide and matrix metalloproteinases are released from damage endothelial cells. The cytokines causes changes in the blood-brain barrier leading to increase in
white blood cells binding. This condition damages the meninges resulting in cerebral edema, clinical presentation of meningitis and even death (Koedel, Klein & Pfister, 2010).
Diagnostic test and treatment for bacterial meningitis:
The suggested diagnostic test that is necessary for Ethan includes blood test, magnetic resonance test and lumbar puncture. The purpose of blood test is to collect sample
of blood identify the bacteria involed in infection and observes the colony morphology of the strain. Imaging test like computerized tomography or magnetic resonance scan is
done to observe signs of swelling and inflammation. In addition, lumbar puncture test is done to collect cerebrospinal fluid and detect changes in white blood cell count ( Kim,
2010).
The best treatment for meningitis in case of Ethan is to provide antibiotics for infection, medication for symptom of high blood pressure and breathing support. The rational
for antibiotic treatment by administering antibiotics kike cephalosporin and tetracycline is that it can reduce infection in affected patient. This can prevent Ethan from neonatal
sepsis. The advantage of antibiotic treatment is that it can stop the growth of bacteria and reduce inflammation of the meninges (van de Beek et al., 2012). As Ethan is an infant
of 18 months, his treatment with ampicillin and gentamicin is necessary to treat neonatal sepsis. While engaging in pharmacological management of meningitis, it is necessary to
consider the age of patient. In addition, oxygen therapy is a form of supportive care that can help to reduce breathing problem in patient. Hence, it can be said that immediately
delivery of intravenous antibiotic and appropriate supportive care are essential elements of treatment for bacterial meningitis (Agrawal & Nadel, 2011)

Reference list
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