Assignment on Liraglutide PDF

BIOCHEMISTRY- LIRAGLUTIDE
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Overview
Liraglutide is a pharmaceutical drug with a long-acting fatty acylated glucagon-like peptide-1
(GLP-1), which is classed as a carboxylic acid REFERENCE. Liraglutide is a once-daily GLP-1
derivative for the treatment of type 2 diabetes, its half-life is approximately 11-15 hours making
it appropriate for once-daily dosing [1]. Enzyme is dipeptidyl peptidase 4
Liraglutide is an injectable glucagon-like peptide (GLP-1) receptor agonist [2]. Which was
approved in 2010 by the US FDA as a treatment for type 2 diabetes mellitus (T2DM) as Victoza,
and more recently has been approved at a higher dose as Saxenda, for chronic weight
management [2]? T2DM is one of the most prevalent metabolic disorders which are
characterized by hyperglycemia due to the detection of insulin secretion or also insulin action
[2]. GLP-1 is a natural incretin hormone which is realized from intestinal L-cells in response to
hormonal, neural and nutrient stimuli [3]. As GLP-1 is used for the treatment of T2DM its half-
life is approximately 11-15 hours, which is suitable for once-daily dosing.
Liraglutide is used with an eating routine as well as exercise program to regulate glucose levels
in grown-ups with sort 2 diabetes (situation where the body does not use insulin typically and in

this way is not able to regulate the amount of sugar in the blood) when different drugs did not
regulate levels alright. Liraglutide is likewise used to diminish the danger of a heart assault,
stroke, or passing in grown-ups with sort 2 diabetes mellitus and heart and vein illness.
Liraglutide is not utilized to treat type 1 diabetes (condition in which the body does not deliver
insulin and along these lines can't control the measure of sugar in the blood) or diabetic
ketoacidosis (a genuine condition that may create if high glucose isn't dealt with) [3].
Liraglutide is utilized alongside a lessened calorie diet and exercise intended to help individuals
who are stout or who are overweight and have weight-related therapeutic issues to get in shape
and to keep from recovering that weight. Liraglutide is not utilized to treat type 2 diabetes.
Liraglutide is in a class of drugs called incretin mimetics [13]. It works by helping the pancreas
to discharge the appropriate measure of insulin when glucose levels are high. Insulin enables the
move to sugar from the blood into other body tissues where it is utilized for vitality. Liraglutide
infusion likewise moderates the exhausting of the stomach and may diminish hunger and cause
weight reduction.
Over the period, individuals who have diabetes and high glucose can create genuine or
dangerous intricacies, including coronary illness, stroke, kidney issues, nerve harm, and eye
issues. Utilizing medication(s), rolling out a way of life improvements (e.g., diet, work out,
stopping smoking), and routinely checking your glucose may deal with your diabetes and
enhance your wellbeing. This treatment may likewise diminish your odds of showing some
kindness assault, stroke, or different diabetes-related confusions, for example, kidney
disappointment, nerve harm (numb, chilly legs or feet; diminished sexual capacity in people),
eye issues, including changes or loss of vision, or gum sickness [4]. Your specialist and other

medicinal services suppliers will converse with you about the most ideal approach to deal with
your diabetes.
Liraglutide injection comes as an answer (fluid) in a prefilled dosing pen to infuse
subcutaneously (under the skin) in your stomach, thigh, or upper arm. It is normally infused once
per day with or without sustenance. Utilize liraglutide infusion at around a similar time each day.
Pursue the bearings on your solution mark deliberately, and ask your specialist or drug specialist
to clarify any part you don't get it. Utilize liraglutide infusion precisely as coordinated [12].
The most common side effects of the drug include:
Irritation of your pancreas (pancreatitis): Quit utilizing Victoza® and call your social insurance
supplier immediately on the off chance that you have serious torment in your stomach territory
(midriff) that won't leave, with or without heaving. You may feel the torment from your guts to
your back.
Low glucose (hypoglycemia): The getting low glucose might be higher on the off chance that
you utilize Victoza® with another drug that can cause low glucose, for example, a sulfonylurea
or insulin [5]. Signs and manifestations of low glucose may include: tipsiness or dazedness,
obscured vision, uneasiness, peevishness or mindset changes, perspiring, slurred discourse,
appetite, disarray or sluggishness, unsteadiness, shortcoming, migraine, quick heartbeat, and
feeling jumpy.
Kidney issues (kidney disappointment): In individuals who have kidney issues, looseness of the
bowels, queasiness, and retching may cause lost liquids (drying out), which may make kidney
issues deteriorate.