Running head: CASE STUDY BASED NURSING ASSIGNMENT Answer 1: Concept Map Figure 1: Concept Map of the given case study Source: (Gosmanov, Gosmanova & Kitabchi, 2018)
Running head: CASE STUDY BASED NURSING ASSIGNMENT Question 2: Essay: Diabetic ketoacidosis (DKA) is a terminal disorder that affects people who have diabetes. The condition that initiates the process of acidosis within an individual with diabetes is when the body starts to break down the fats at a much higher rate. The liver is the organ responsible for the ketone of fat into a compound known as ketones.Ogawa and Sakaguchi(2016) opined that the ketone would make the blood acidic in nature, causing a multitude of issues in the patients. The essay aims to highlight the case study of Carly’s, a 12 years old girl who was admitted to the emergency department. She was admitted to the hospital because of drastic weight loss in a short period and there was a history of polydipsia, polyuria and febrile illness for two weeks. In recent times, she has developed nausea, abdominal pain, and vomiting tendency. Various signs and symptoms were indicating the condition to be DKA. The explanation of the pathophysiology related to each of the signs and symptoms, as well as the test conducted upon Carly, will be assessed in gaining in-depth knowledge of the disorder as well as the neurological deficit found in the case study will be reviewed. One of the important factors that need to be understood in having an in-depth knowledgeofdiseaseispathophysiology.Pathophysiologyisdisorderedphysiological processes that are associated with a particular injury or disorder. Thus, it is an abnormal state of a specific disorder or functional changes occurring in the body due to a disorder or its syndrome. According toFarsaniet al. (2017), DKA is stated to be associated with insulin deficiency and the elevated level of blood glucose that is thought to be over 300 mg/dL. Because of the fact, the tissue within the body, including muscle, fat and the liver, cannot use the glucose or take up for their activities. Even though the blood has an elevated amount of glucose, however, the cells starve due to the absence of insulin in the body. This is because
1CASE STUDY BASED NURSING ASSIGNMENT the brain-blood barrier does not require insulin for the diffusion of glucose across the blood as a result of which the brain cells have an optimum level of glucose in them. Therefore, the patient experienced several signs and symptoms that indicate hyperglycemia (Jia, Whaley- Connell & Sowers, 2018). The blood glucose level of Carly indicated that she had diabetes where the blood sugar level was extremely high as the normal range is 3.9 to 7.1 mmol/L. From the study ofKocheret al. (2018), it can be stated that there are several complications related to this condition, such as increase chance of cardiovascular diseases, damage to kidney, nerve and even the blood vessel in the retina that can potentially cause blindness. In case of a persistent period of such level of blood glucose level in the body that was observed in this case study, it had led to a condition known as diabetic ketoacidosis where relative no insulin is present in the body. In addition to this, another emergency complication that occurs is the hyperglycaemic hyperosmolar rate where insulin is produced within the body; however, the utilisation does not occur. The low concentration of sodium states that hypernatremia and high level of potassium state hyperkalaemia, which are both severe in nature that can lead to heart, a disorder in patients. The pathophysiological syndromes that are associated with the elevated level of blood glucose in DKA are metabolic acidosis, electrolyte disturbance and osmoticdiuresis.Umpierrez(2019)opinedthatelectrolytedisturbanceinvolvesan abnormality in the concentration of the electrolytes in the human body. The ions are found to play a vital role in the maintenance of homeostasis and help in the regulation of the neurological and heart function, oxygen delivery, fluid balance, and acid-base balance in the body. The function of the kidney is affected due to such imbalance and leads to inappropriate urination (Jayashree, Williams & Iyer, 2019). An electrolyte test was conducted in order to measure the sodium and potassium levels in the body, which is necessary for confirming the disorder. From the test result, it was found that the sodium level in the serum was 128 mmol/L, and potassium level was 6.3 mmol/L. As per the information, the normal blood
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2CASE STUDY BASED NURSING ASSIGNMENT sodium level is found to be 135 to 145 mmol/L indicates that the sodium level is low in Carly’s body. In contrast, the potassium level needs to be 3.6 to 5.2 mmol/L indicating that this is higher in the case study. According toAli and Yun(2016), the optimal balance of sodium and potassium is essential for life as the molecular pumps maintain the balance thus, creating a chemical battery thus, and support in the transmission of signals from the nerves and provide energy for the contraction of the muscles. This balance of sodium and potassium is useful because it helps the kidney to work properly as it is important in fluid balance and energy production. Due to an imbalance in sodium-potassium level, Carly’s kidney could not work accurately, leading to various complications such as breaking down of fats at a higher rate leading to the production of ketones. After Carly was admitted to the emergency department, the test that was conducted upon her was an arterial blood gas analysis, which is measured for measuring the acid level and the level of oxygen and carbon dioxide present in the blood supplied by the artery.Dancer and Thickett(2020) opined that the test was used for assessing the capability of the lungs to move the oxygen into the blood and removal of the carbon dioxide from it. From the case study, it was demonstrated that the pH level was 7.06 states that the lungs are slightly alkaline in nature whereas the Partial pressure of carbon dioxide (PaCO2) was ten mmHg, which is far less than the normal values, where the normal valuesofPaCO2are38-42mmHg.Fromtheanalysis,theseverityofacidosiswas determined. As per the study conducted byTobitaet al. (2016), it can be stated that the accumulation of acid within the body disrupted the normal balance and optimal health. The most affected organ, in this case, are the lungs and kidneys whose normal functioning is hampered to a large extent as a result of which the body is put under tremendous stress thus, causing several complications. A number of factors can be responsible for causing an increased level of acid in the body that require further investigation in the case study. In addition to conducting arterial blood gas analysis, further tests were conducted that presented
3CASE STUDY BASED NURSING ASSIGNMENT the following results were obtained. As per the study ofNewman and Verdin(2017), the chemical compound,β-hydroxybutyrate (β-HBO), is used as a form of energy that is utilised by some of the cells in case the sugar levels are low and help the brains and nervous system to act properly. The reference range ofβ-hydroxybutyrate (β-HBO) level is less than to 0.4 to 0.5 mmol/L, whereas in the case study an elevatedβ-hydroxybutyrate (β-HBO) level was 1.9 mmol/L was observed. The high level of the chemical compound directly indicates conditions such as insulin deficiency, a disorder related to the metabolic substrate and altered status of the redox reaction. All these conditions directly indicate that the patient was suffering from DKA as the production of ketones in the body is observed to be stimulating insulin deficiency and dehydration. Using a C - reactive protein test, it was found that there was an elevated level in the sensitivity of Hs-CRP to be 10.3 mg/L in the case study. Another condition that is associated with the pathophysiology of the disease was osmotic diuresis, which involves an increase in the rate of urination due to the presence of small tubes in the kidney (Patel et al., 2018). The process of excretion occurs when substances such as glucose are present in the kidney tubules; however, it cannot be reabsorbed due to the abnormal pathological state in the body. It can occur in another case where various substances are found in increase concentration in the circulation as a result of which it increases the osmolarity in the blood. As per the case study, it can be found that Carly’s have diabetes and the condition such as polyuria and polydipsia were found to be occurring in the patient for a period of two weeks prior to admission in the emergency department. The CRP is produced in the liver and a rise in the level of the protein from the normal range leads to inflammation in the body.de Queiroz Melloet al. (2018) opined that the presence of low-density lipoprotein (LDL) cholesterol would coat the walls of the arteries and thus, damages it. In order to mitigate the condition, the body itself sends a response team compromising a number of proteins, and one of them includes CRP. From the study conducted byAlthaus et al.(2019), it was stated that
4CASE STUDY BASED NURSING ASSIGNMENT testing the CRP level was more significant as an indicator of cardiovascular disease (CVD) than the LDL test. The count of white blood cells (WBCs) had demonstrated an immature band cell. According toHernández-Castroet al. (2019), WBCs are a heterogeneous group of nucleated cells that are found in the circulation and the concentration in the blood is in the range of 4000 to 100000 per microliter. The role of the cells is found in phagocytosis and immunity, and it is one of the major players in the defence system against any kind of infection. According to the information available related to band cells, it could be noted that these cells are an immature form of the neutrophils that are commonly found to produce WBCs. As stated earlier, these are used as a defence mechanism in the body as a result of which, these are produced extensively by the body in case of any infection. The drowsiness of the patient, Carly, was evaluated using the Glasgow Coma Score (GCS), which was 12 (E3+V4+M5). According toDiBritoet al. (2018), the use of GCS was used for assessing the patients in coma, since Carly was drowsiness, the possibility of coma or the presence of any brain injury was evaluated using the score. From the score, it was found that there was a moderate head injury where the eye response indicated that she was open to verbal command as when she was asked to arise, she responded to it. The verbal response rate was four that indicated she was confused, and the motor response was 5, indicating localising pain. After the administration of intravenous fluid and insulin, her condition improved. After six hours, neurological deterioration occurred. The condition deteriorates further where she had a self- terminating tonic-clonic seizure and she became unaroused. The GCS was six; eye and verbal responses were constantly reducing. Thus, she was intubated and was given mannitol that leads to the improvement of the condition. The essay can be concluded by stating that Carly, the patient in the case study, was suffering from diabetic ketoacidosis, a severe and complex life-threatening disorder who had diabetes. The condition may be triggered due to some underlying factors that require
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5CASE STUDY BASED NURSING ASSIGNMENT investigation. After admission to the emergency ward where various kinds of tests were conducted to identify the condition. After identification, medications and treatment were initiated within 3-4 hours of admission. Therefore, it can be stated that further evaluation and assessment of the patient was important for understanding the underlying factors that may be responsible for the development of diabetic ketoacidosis. From the thorough evaluation of the case study related to Carly, it was confirmed that she had a previous condition of diabetes where insulin was not produced, and due to improper functioning of the kidney because of the condition, it had led to diabetic ketoacidosis. Thus, it improved neurological deficits after a week and was discharged from the hospital by the administration of mannitol and was intubated that improved the GSC score on further assessment. As per the finding, it can be stated that immediate attention was required in the case that helped in treating the patient with success. Even though it needs to be noticed that the condition cannot be managed; however, it was controlled with the use of medication and effective treatment that helped her to go home.
6CASE STUDY BASED NURSING ASSIGNMENT References Ali, A., & Yun, D. J. (2016). Differential selection of sodium and potassium ions by TsHKT1;2.Plantsignaling&behavior,11(8),e1206169.Doi: https://doi.org/10.1080/15592324.2016.1206169 Althaus, T., Greer, R. C., Swe, M. M. M., Cohen, J., Tun, N. N., Heaton, J., ... & Doran, Z. (2019). Effect of point-of-care C-reactive protein testing on antibiotic prescription in febrile patients attending primary care in Thailand and Myanmar: an open-label, randomised,controlledtrial.TheLancetGlobalHealth,7(1),e119-e131.Doi: https://doi.org/10.1016/S2214-109X(18)30444-3 Dancer, R., & Thickett, D. (2020). Assessment of pulmonary function.Medicine. de Queiroz Mello, A. P., Albattarni, G., Espinosa, D. H. G., Reis, D., & Neto, A. M. F. (2018). Structural and nonlinear optical characteristics of in vitro glycation of human low-density lipoprotein, as a function of time.Brazilian Journal of Physics,48(6), 560-570. Doi:https://doi.org/10.1007/s13538-018-0600-x DiBrito, S. R., Cerullo, M., Goldstein, S. D., Ziegfeld, S., Stewart, D., & Nasr, I. W. (2018). Reliability of Glasgow Coma Score in pediatric trauma patients.Journal of pediatric surgery,53(9), 1789-1794. Doi:https://doi.org/10.1016/j.jpedsurg.2017.12.027 0022- 3468/ Farsani, S. F., Brodovicz, K., Soleymanlou, N., Marquard, J., Wissinger, E., & Maiese, B. A. (2017). Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetesmellitus(T1D): a systematicliteraturereview.BMJ open,7(7), e016587.Doi: http://dx.doi.org/10.1136/bmjopen-2017-016587
7CASE STUDY BASED NURSING ASSIGNMENT Gosmanov, A. R., Gosmanova, E. O., & Kitabchi, A. E. (2018). Hyperglycemic crises: diabeticketoacidosis(DKA),andhyperglycemichyperosmolarstate(HHS). InEndotext [Internet]. MDText. com, Inc. Hernández-Castro, J. A., Li, K., Daoud, J., Juncker, D., & Veres, T. (2019). Two-level submicron high porosity membranes (2LHPM) for the capture and release of white bloodcells(WBCs).LabonaChip,19(4),589-597.Doi: https://doi.org/10.1039/C8LC01256C Jayashree, M., Williams, V., & Iyer, R. (2019). Fluid therapy for pediatric patients with diabeticketoacidosis:currentperspectives.Diabetes,MetabolicSyndromeand Obesity: Targets and Therapy,12, 2355. Doi:10.2147/DMSO.S194944 Jia,G.,Whaley-Connell,A.,&Sowers,J.R.(2018).Diabeticcardiomyopathy:a hyperglycaemia-and insulin-resistance-induced heart disease.Diabetologia,61(1), 21- 28. Doi:https://doi.org/10.1007/s00125-017-4390-4 Kocher, T., König, J., Borgnakke, W. S., Pink, C., & Meisel, P. (2018). Periodontal complications of hyperglycemia/diabetes mellitus: epidemiologic complexity and clinical challenge.Periodontology 2000,78(1), 59-97. Doi:10.1111/prd.12235 Newman, J. C., & Verdin, E. (2017). β-Hydroxybutyrate: a signaling metabolite.Annual review of nutrition,37, 51-76. Doi:10.1146/annurev-nutr-071816-064916 Ogawa, W., & Sakaguchi, K. (2016). Euglycemic diabetic ketoacidosis induced by SGLT2 inhibitors:possiblemechanismandcontributingfactors.Journalofdiabetes investigation,7(2), 135-138. Doi:https://doi.org/10.1111/jdi.12401 Patel, S. M., Hickman, M. A., Frederich, R., Lauring, B., Terra, S., Johnson, S. L., ... & Mancuso, J. P. (2018). Evaluation of Osmotic Diuresis and Volume Depletion Events
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8CASE STUDY BASED NURSING ASSIGNMENT in Patients with Type 2 Diabetes Mellitus (T2DM) Receiving Ertugliflozin. Doi: https://doi.org/10.2337/db18-1169-P Tobita, T., Guzman-Lepe, J., Takeishi, K., Nakao, T., Wang, Y., Meng, F., ... & Soto- Gutierrez, A. (2016). SIRT1 disruption in human fetal hepatocytes leads to increased accumulationofglucoseandlipids.PLoSOne,11(2).Doi: 10.1371/journal.pone.0149344 Umpierrez, G. E. (2019). Diabetic Ketoacidosis. InThe Diabetes Textbook(pp. 619-627). Springer, Cham.