Concept of Cystic Fibrosis | Biology Assignment

Running head: BIOLOGY
CYSTIC FIBROSIS
Name of the Student
Name of the University
Author Note

BIOLOGY1
Table of Contents
Background......................................................................................................................................2
Research question............................................................................................................................3
Methodology....................................................................................................................................3
Expected outcome............................................................................................................................6
Benefits of research.........................................................................................................................7
Dissemination plan..........................................................................................................................8
References........................................................................................................................................9

BIOLOGY2
Background
Cystic fibrosis has been identified as an inherited disease that is characterized by a thick buildup
of mucous which damages the body organs. The disorders have been found as the most common
symptoms and signs including progressive damage to chronic digestive problems and respiratory
systems. The main feature of this disorder has been identified as the variation of severity among
the individuals. Mucus has been identified as the slippery substances which protect and lubricate
the digestive system linings associated with the digestive system, airways, reproductive system,
and other tissues and organs. The abnormal mucus has been found to clog the airways which
leads to severe problems associated with bacterial infections and breathing rates (Farrell et al.,
2017).
Cells that are both eukaryotic and prokaryotic are found to be surrounded by a plasma
membrane that defines the cell boundary which separates the internal cell constituents from the
external environment. After working as a selectively permeable barrier for the passage of
molecules, this plasma membrane has been found to determine the cytoplasmic composition. The
plasma membrane determines the identity of the cell and that is the reason why the plasma
membrane is known as the most fundamental structure of cell evolution (Cooper, 2019). The
most primitive is thought to have arisen from the enclosure of self-replicating RNA in the
phospholipid membrane. The general structure of the plasma membrane in the present day has
been observed to be semipermeable in nature and is also found to be impermeable to most of the
water-soluble molecules. The regular passage of organic molecules and ions across the plasma
membrane has been found to be mediated by the membrane that is responsible for molecular
traffic both in and out of the respective cells.

BIOLOGY3
Many people have been found to be affected by cystic fibrosis which is associated with
digestive problems caused by cystic fibrosis. Digestive problems have been found to result from
the buildup of thick mucus that clogs the airways leading to serious breathing problems. Cystic
fibrosis has been found to be considered a childhood disease. CFTR (cystic fibrosis
transmembrane regulator protein) has been found to act as a membrane protein associated with a
chloride ion channel. The gene associated with this protein has been found to code for an ABC
transporter ion channel protein which conducts chloride ions across the epithelial cell membranes
(Gentzsch & Mall, 2018). This disease has been found to occur when the transmembrane
regulators are not synthesized correctly. Mutations in CFTR have been found to affect the
chloride ion transport channels that are associated with frequent mucus infections. This paper
will discuss the association of cystic fibrosis with the plasma membrane and the genetic basis of
associated disease.
Research question
This section will point out the questions that will be answered in this research proposal
associated with the association of cystic fibrosis with the plasma membrane. Since from the
background, it can be seen that the plasma membrane is an important component of cells, three
significant questions will be answered in this paper. The research questions have been given
below:
RQ1: Why is cystic fibrosis associated with the plasma membrane.
RQ2: What is the genetic basis of cystic fibrosis.