Covid-19: Is it Manmade?

This report discusses the debate on whether Covid-19 is manmade or not. It explores the origins of the virus and presents evidence from various academic sources. The conclusion highlights the need for a deeper understanding to prevent future manmade epidemics.

Covid-19 is it
Manmade

Table of Contents
INTRODUCTION.................................................................................................................................3
MAIN BODY........................................................................................................................................3
CONCLUSION.....................................................................................................................................5
REFERENCES......................................................................................................................................6

INTRODUCTION
Covid-19 (Coronavirus disease) is an infectious disease originated by a latest findings
coronavirus. Large audience infected with the coronavirus disease would develop light to moderate
inhaling illness & retrieve without specific treatment. The elderly & those with fundamental
conditions such as cardiovascular disease, chronic respiratory diseases, diabetes, as well as cancer are
increased likely to generate serious illnesses (Coronavirus, 2020). The best method to prevent &
delay the spread is to fully understand the coronavirus, the diseases it causes, & how it rolls out. Wash
your hands often or use alcohol-based wipes and do not touch your face to protect yourself & others
from infection. The corona virus is mainly transmitted through droplets of saliva or nasal secretions
when an infected patient sneezes or coughs, so it is significant to practice breathing etiquette as well.
The present report talks about the discussion upon the Covid-19 it is manmade along with the current
trends as well as arguments from various academic sources.
MAIN BODY
In the year 2015, the Wuhan Institute of Virology (WIV) became the National
Biosafety Laboratory (Level 4), which was the first laboratory of its kind in China at a range
of 300 million Yuan ($ 44 million). The laboratory is included in the investigation of
coronavirus pathogens and the 2003 outbreak of critical acute inhaling syndrome (SARS). An
author published a report on bat species as natural hosts for SARS-like coronaviruses, noted
the transmitted variety of viruses in bats, and emphasized their possibility of infecting
humans. When civet cats come into contact with humans in live animal markets, civet cats
can infect humans. Since the covid-19 clusters in bats are limited, the possibility of this virus
outbreak in the future has never been predicted. Although, when a chimeric virus comprising
the SHC014 peak in the SARS-covid-19 backbone was shown to cause severe infections in
people’s respiratory cultures & mice, issued a warning that the newly emerged SARS-like
pressure. These required items are previously circulating in the animal host. A Chinese
research team spent five years selecting bats in Stone Cave, Yunnan, and issued a similar
alarm & warned that if proper measures are not taken, disease outbreaks may occur. In year
December 2019, China reported the 1st group of new coronavirus infection cases. The
present novel coronavirus SARS-CoV-2, focusing on PID in Hubei Province of the People’s
Republic of China, has flourished too numerous other nations. On January 30, 2020, the
World health organisation Emergency Committee announced a worldwide health emergency
dependent on the rising case information rate in China & internationally. The case

observation rate modifies every day & can be measured in near real-time on websites made
available by Johns Hopkins University 1 & other platforms (Is Covid-19 man-made? 2020).
As of mid-February 2020, China has a heavy burden of mortality & morbidity, while
the morbidity rates in other Asian nations, Europe & North America are still at fewer levels
so far. The coronavirus is a positive single-stranded huge RNA virus with an envelope that
can infect humans, but it can also infect many creatures. The coronavirus was 1st mentioned
by Tyrell & Bynoe in 1966, which cultured the virus from people with the common cold.
Dependent on their morphology, spherical viral particles with a central layer and corona-like
surface bumps are called coronaviruses. There are four subfamilies, that is, coronaviruses α,
β, γ, and δ. Although α & β coronaviruses apparently originated in mammals, especially bats,
the γ and δ viruses originated in pigs & birds. The size of the genome distinct between 26 kb-
32 kb. Among the 7 subtypes of covid-19 that could infect humans, β-coronaviruses can
cause critical illness and death, while α-coronaviruses can cause asymptomatic or lightly
symptomatic infections. SARS-CoV-2 belongs to the B lineage of β-coronavirus & is closely
related to SARS-CoV 3 and 4. The 4 main structural genes encode spike protein (S), small
membrane protein (SM) nucleocapsid protein (N), & membrane glycoprotein (M), as well as
other membrane sugars present in β-coronavirus HCoV-OC43 & HKU1 Protein (HE) 5.
SARS-CoV-2 is 96 per cent identical to bat coronavirus at the whole genome level. Provided
the weak health systems in major sub-Saharan African nations, latest & re-emerging disease
outbreaks, like the current COVID-19 pandemic, may weaken the health system at the cost of
the health sector’s primary care needs.
Five years later, the effect of the Ebola epidemic on the economic & health structures
of the affected countries still exists. Effectively responding to the epidemic and preparing for
an emergency of this scale are issues facing Africa & other less- and middle-income nations.
These conditions could only be partially alleviated by supporting the existing regional & sub-
Saharan health structures in sub-Saharan regions. On 6 Feb, 2020, scientists from South
China University mentioned out that the halfway host horseshoe bats could not be found in
the wet market & did not present in the Wuhan area. The only location where bats present is
the research facility that is about hundred meters away from the Wuhan wet market.
Horseshoe bats are only found in Yunnan province. Although, they were not utilised as food
in cities or sold in the market. The document also noted that at the Wuhan Center for Disease
Control & Prevention, which is 280 meters away from the market, extraction & sequencing of
DNA as well as RNA from caged animals can be a competent source of pathogens. The
centre is also adjoining to the Xiehe Hospital, which was the place where the 1st group of

doctors were contaminated in the epidemic. Interestingly, the lead author has renounced the
article, quoting it was dependent on speculation rather than hard evidence.
To have a practical view of this issue, we must study the arguments in opposition to
the development of the COVID-19 laboratory. Rhinolophus affinis bats & Malayan pangolins
comprise CoVs common to SARS-CoV-2. Although, the receptor-binding domain (RBD) of
viruses is isolated from these 2 sources is significantly variants from the RBD of human
SARS-CoV-2 that has a fewer affinity for the angiotensin-converting enzyme 2 (ACE2)
receptor. In theory, this might indicate the host animal's natural selection process prior to
transfer. Another, this adaptation can develop after zoonotic infections are transmitted to
humans. The ancestors of SARS-CoV-2 post infection with humans might have grasped
genomic characteristics through conversion during the process of undiscovered person-to-
person transmission. Retrospective serologic studies can answer such queries. Finally, the
optimal RBD hierarchy for the people receptor assumed using the computer model is
relevantly different from the RBD hierarchy isolated from humans with huge binding affinity.
If artificial engineering is the source, this specific RBD hierarchy will not be favoured
because it does not have the huge binding affinity assumed by the computer framework. This
emphasizes the chances of natural selection (The COVID‐19 epidemic, 2020).
CONCLUSION
From the above report, it can be concluded that there are huge evidence seems to support the
phenomenon of a man-made virus which was leaked from the laboratory to the community. However,
it looks immoral to blame other places when we have to work hard, people can’t be satisfied with the
evidence that proves otherwise to the theory of community origins proposed by the Chinese
government. The healthcare community must understand this deeply to safeguard man-made
epidemics in the future, because otherwise we may never have the chance.

REFERENCES
Online
Coronavirus, 2020 [online] Available through <
https://www.who.int/health-topics/coronavirus#tab=tab_1>
Is Covid-19 man-made? 2020 [online] Available through
https://www.crstonline.com/article.asp?issn=2590-
3233;year=2020;volume=3;issue=2;spage=284;epage=286;aulast=Chaturvedi
The COVID‐19 epidemic, 2020 [online] Available through
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169770/