This essay explores the medical references in Charlotte Perkins Gilman’s “The Yellow Wallpaper” and examines how the story comments on Victorian-era medical practices and beliefs. The narrator, diagnosed with neurasthenia, is subjected to a treatment that suppresses her creativity and reinforces the oppressive and sexist medical doctrine of the time. The story uses the yellow wallpaper as a symbol of the domestic world that traps women. References to medical theories and diseases prevalent in the Victorian era are also discussed.