This nursing assignment delves into the complex ethical dilemmas encountered by nurses in clinical practice. It focuses on the tension between respecting patient autonomy and providing beneficent care, particularly when patients refuse treatment like antiretroviral therapy (ART) due to personal beliefs. The paper analyzes a case study of a patient with AIDS who refuses ART, highlighting the conflicting ethical principles involved. It also discusses the impact of unresolved ethical dilemmas on nurses' well-being and patient safety, emphasizing the importance of ongoing ethical reflection and education in nursing practice.