Acute Life-Threatening Conditions: Pathogenesis, Clinical Manifestations, and Treatment

Health Variations 4:
Acute Life-
Threatening
Conditions

Table of Contents
INTRODUCTION...........................................................................................................................3
MAIN BODY...................................................................................................................................3
Q1) Explain the pathogenesis causing the clinical manifestations with which Poppy presents
................................................................................................................................................3
Q2) Step 1: Sit Poppy in a High Flowers position.................................................................4
Q3) some of the question:.......................................................................................................5
REFERENCES................................................................................................................................8

INTRODUCTION
An apparent life threatening condition is known as the channel of frightening to the
observer and this is identified by some combination which is associated with the aponea that is
may be central and obstructive. As per this, there is some question which is answered to provide
the pathogenesis of poppy. In context with this, the position of poppy and also there are number
of drug which is used define drug of mechanism of action. Baker and et. al., (2020).
MAIN BODY
Q1) Explain the pathogenesis causing the clinical manifestations with which Poppy presents
Asthma is a condition in which the inflammation of the airway causes narrowing of
airway which then reduces the flow of air in and out of lungs resulting in breathlessness. Chen
and et. al., (2018). Asthma histopathological features include cell inflammation due to internal or
environmental factors. The most common form of asthma in children is atopic asthma. This is
classified by the presence of immunoglobulin E(IgE) which are allergen sensitive antibodies. In
Poppy’s case her infrequent episodic asthma would be atopic triggered by external factors
including pollen and or dust. Hussain (2019). . The Pathogenesis of asthma mainly includes two
factors genetic and environmental factor as allergens play an important role in pathogenic of
asthma. When a person inhales any allergen, they reach to epithelium of the trachea or bronci. As
poppy inhales an allergen it travels the conducting passage of her respiratory system to the lining
of the trachea and bronchi known as pseudostratified epithelial tissue. Antigen-presenting cells
known as dendritic cells, react to the allergen by triggering an immunohistopathology response.
The T cells activate T helper type 2 (Th2) cells. Th2 cytokines modulate cell hyperplasia through
interleukin-13 inducing airway hyperresponsiveness (AHR). Plasma cells are stimulated due to
the release of cytokines and leukotrienes, resulting in IgE antibodies. Ige antibodies bind to mast
cells allowing both histamines prostaglandins and leukotrienes to release. Due to this rapid
response compounds known as histamines cause a pro inflammatory reaction, ultimately leading
to bronchoconstriction. Bronchoconstriction is the contraction of smooth bronchus muscles
emanating AHR. The inflammatory reaction of Poppy airways has led her airways to a state of
hyper-responsiveness and bronchospasms. As a result of this episode poppy respiratory
symptoms worsen over time leading to breathlessness and ultimately chronic respiratory disease
if left untreated. Poppy’s oxygen saturation levels (Spo2) are at 87% on room air, showing she is