Annotated Bibliography on Heart Failure Management and Dietary Advice
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This annotated bibliography provides a review of various interventions that provide information on dietary advice to manage cardiovascular diseases and conditions, and the impact of different Heart failure (HF) disease management programs (DMPs) to minimize hospital readmission of people suffering heart failure. The study findings indicate the potential of telemanagement DMP and structured telephone support DMP to control hospital readmission, the positive impact of dietary advice on cholesterol levels, triglyceride levels, blood pressure, urinary sodium excretion, and the positive impact of nurse-led heart failure clinic interventions on self-care behaviour development and survival. The study provides reliable and specific information that can be used to develop nursing interventions for patients with chronic heart failure.
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RESEARCH IN NURSING
(ASSESSMENT – 2)
1
(ASSESSMENT – 2)
1
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Part- 1 Annotated Bibliography
Gorthi, J., Huntera, C. B., Mooss , A. N., Alla, V. M., & Hilleman, D. E. (2014).
Reducing heart failure hospital readmissions: A systematic review of disease
management programs. Cardiology Research, 5, 126-138.
Gorthi et al. (2014) conducted a systematic review analysis of various
researches that use different heart failure (HF) disease management programs (DMPs)
to minimize hospital readmission of people suffering heart failure. The study aim was
to evaluate available researches conducted to determine the efficiency of DMPs in
controlling hospital readmission of people with chronic HF. The review data involved
on-line authentic research studies randomly collected from reliable resources like
PubMed, Cochrane library and EBSCOHost from the year 1975 to 2014. The research
studies analyzing DMPs on more than 50 patients were included in review analysis.
The efficiency was analyzed on the basis of hospital readmission or mortality
outcomes. The DMPs analyzed in the review were outpatient clinic care, home visits,
telemonitoring (invasive and non-invasive) and structured telephonic support. As per
findings, telemanagement DMP showed potential to reach a wide range of patients at
one time in cost effective manner as well as structured telephone support DMP
showed a control in HF hospital readmission. The home visits and outpatient clinic
care were limited in terms of accessibility and cost to control hospital readmission.
Thus, the review findings provide inconsistent results and cannot be considered
potentially effective to interpret the effect of HF DMPs.
Rees, K., Dyakova, M., Wilson, N., Ward, K., Thorogood, M., & Brunner, E.
(2013). Dietary advice for reducing cardiovascular risk. Cochrane Database of
Systematic Reviews, 2013(12), 1-113.
Ress et al. (2013) provided a review of various interventions that provide
information on dietary advice to manage cardiovascular diseases and conditions. The
study aims to provide effective dietary advice that can help to improve cardiovascular
risk profile among adults 18 or above dwelling in the community. There were less
than 25% participants diagnosed with cardiovascular disease. Only 10% participants
were allowed to use pharmaceuticals as per essentiality. The participants included
2
Gorthi, J., Huntera, C. B., Mooss , A. N., Alla, V. M., & Hilleman, D. E. (2014).
Reducing heart failure hospital readmissions: A systematic review of disease
management programs. Cardiology Research, 5, 126-138.
Gorthi et al. (2014) conducted a systematic review analysis of various
researches that use different heart failure (HF) disease management programs (DMPs)
to minimize hospital readmission of people suffering heart failure. The study aim was
to evaluate available researches conducted to determine the efficiency of DMPs in
controlling hospital readmission of people with chronic HF. The review data involved
on-line authentic research studies randomly collected from reliable resources like
PubMed, Cochrane library and EBSCOHost from the year 1975 to 2014. The research
studies analyzing DMPs on more than 50 patients were included in review analysis.
The efficiency was analyzed on the basis of hospital readmission or mortality
outcomes. The DMPs analyzed in the review were outpatient clinic care, home visits,
telemonitoring (invasive and non-invasive) and structured telephonic support. As per
findings, telemanagement DMP showed potential to reach a wide range of patients at
one time in cost effective manner as well as structured telephone support DMP
showed a control in HF hospital readmission. The home visits and outpatient clinic
care were limited in terms of accessibility and cost to control hospital readmission.
Thus, the review findings provide inconsistent results and cannot be considered
potentially effective to interpret the effect of HF DMPs.
Rees, K., Dyakova, M., Wilson, N., Ward, K., Thorogood, M., & Brunner, E.
(2013). Dietary advice for reducing cardiovascular risk. Cochrane Database of
Systematic Reviews, 2013(12), 1-113.
Ress et al. (2013) provided a review of various interventions that provide
information on dietary advice to manage cardiovascular diseases and conditions. The
study aims to provide effective dietary advice that can help to improve cardiovascular
risk profile among adults 18 or above dwelling in the community. There were less
than 25% participants diagnosed with cardiovascular disease. Only 10% participants
were allowed to use pharmaceuticals as per essentiality. The participants included
2
children, pregnant women and weight reducing people. The review method involved
randomly controlled trails involving group or individual level studies on dietary
intake and follow up of minimum three months to four years. The dietary
interventions involved only advice related to diet like minimizing fat intakes, food
modifications, vegetable and fruit intake etc. The outcome methods were biomarkers,
cardiovascular risk factors and self-report by participants. The study findings
indicated a remarkable change in cholesterol levels, triglyceride levels, blood
pressure, urinary sodium excretion indicating the positive response of dietary advice
provided in review studies. The self-report by participants indicated increase in fiber
intake, development of healthy eating habits and increase in energy levels. Lastly, this
review study provided lot information on the impact of changing dietary intake on
cardiovascular risk. The results obtained are highlighting a positive change
minimizing cardiovascular risk along with the change in cholesterol and blood
pressure risk of the participants.
Stromberg, A., Martensson, J., Fridlund, B., Levin, L-A., Karlsson, J-E., &
Dahlstrom, U. (2003). Nurse-led heart failure clinics improve survival and self-
care behaviour in patients with heart failure: Results from a prospective,
randomised trial. European Heart Journal, 24, 1014-1023.
Stromberg et al. (2003) provide a study on clinical survival and self-care behaviour
practices provided by nurses led to heart failure clinic. The study aim is to analyse the impact
of nurse-led heart failure clinic on the self-care behaviour, mortality and morbidity of patients
admitted to hospital due to heart failure. The research method involved 106 participants who
were admitted to clinic affected by heart failure or having symptoms or risk of heart diseases.
The follow-up from these patients was collected in visits performed after 2-3 weeks of
discharge up to 12 months. Most educated and experienced nurses were provided
responsibility to manage medication protocols, educate patients and provide treatment in
follow-up visits. The research data was compared to control group data where participants
getting usual care were the control group. The research findings indicated a positive impact of
nurse-led care interventions on target population because the hospital admission due to death
or chronic heart failure condition were very few among target participants when compared to
control group getting usual interventions. There is 55% decrease detected after 12 months of
implementing the intervention indicates a positive impact of self-care education and nurse-led
clinic interventions. Further, study group even had higher self-care score of 3 compared to
control group. Therefore, the study concludes that nurse-led heart failure clinical interventions
3
randomly controlled trails involving group or individual level studies on dietary
intake and follow up of minimum three months to four years. The dietary
interventions involved only advice related to diet like minimizing fat intakes, food
modifications, vegetable and fruit intake etc. The outcome methods were biomarkers,
cardiovascular risk factors and self-report by participants. The study findings
indicated a remarkable change in cholesterol levels, triglyceride levels, blood
pressure, urinary sodium excretion indicating the positive response of dietary advice
provided in review studies. The self-report by participants indicated increase in fiber
intake, development of healthy eating habits and increase in energy levels. Lastly, this
review study provided lot information on the impact of changing dietary intake on
cardiovascular risk. The results obtained are highlighting a positive change
minimizing cardiovascular risk along with the change in cholesterol and blood
pressure risk of the participants.
Stromberg, A., Martensson, J., Fridlund, B., Levin, L-A., Karlsson, J-E., &
Dahlstrom, U. (2003). Nurse-led heart failure clinics improve survival and self-
care behaviour in patients with heart failure: Results from a prospective,
randomised trial. European Heart Journal, 24, 1014-1023.
Stromberg et al. (2003) provide a study on clinical survival and self-care behaviour
practices provided by nurses led to heart failure clinic. The study aim is to analyse the impact
of nurse-led heart failure clinic on the self-care behaviour, mortality and morbidity of patients
admitted to hospital due to heart failure. The research method involved 106 participants who
were admitted to clinic affected by heart failure or having symptoms or risk of heart diseases.
The follow-up from these patients was collected in visits performed after 2-3 weeks of
discharge up to 12 months. Most educated and experienced nurses were provided
responsibility to manage medication protocols, educate patients and provide treatment in
follow-up visits. The research data was compared to control group data where participants
getting usual care were the control group. The research findings indicated a positive impact of
nurse-led care interventions on target population because the hospital admission due to death
or chronic heart failure condition were very few among target participants when compared to
control group getting usual interventions. There is 55% decrease detected after 12 months of
implementing the intervention indicates a positive impact of self-care education and nurse-led
clinic interventions. Further, study group even had higher self-care score of 3 compared to
control group. Therefore, the study concludes that nurse-led heart failure clinical interventions
3
can help to minimise the impact of risk developed after heart failure as well as help patient to
develop a self-care attitude.
Part -2 Justification for selecting these references
Gorthi et al. (2014) review on different researches conducted to analyze the
impact of different Heart failure (HF) disease management programs (DMPs) can be
considered as a reliable source of information because the database is collected from
most authentic websites providing reliable information. This information about
hospital readmission DMPs can be used to manage the condition of Charlie because
he is confronting hospital readmission as an outcome of chronic heart failure he had 2
years before. Heidenreich et al. (2013) indicated that nursing interventions in
managing the chronic condition like heart failure, stroke, kidney disease, infection etc.
play a very important role to minimize the ruthlessness of that condition.
This review study can be considered as a reliable resource in terms of quality
because study data is collected from most reliable online websites. Secondly, the
methodology, sample researches and analysis tools are crucially analysed to gather
best possible outcomes. The review findings include the use of proper statistics that
provided most authentic outcomes. The review clearly mentions that the outcome
obtained about studied DMPs are not sufficient to determine the efficiency of HF
disease management program proves its reliability.
In the review different DMPs working on wide range of population are
compared to analyze the effect on hospital readmission after heart failure incidence.
Out of these DMPs, telemonitoring and structured telephone support are considered as
effective DMPs to control hospital readmission. These DMPs can be used as a part of
the nursing care plan to manage Charlie condition in provided case.
According to Yancy et al. (2013) studies diet is an important factor for chronic
heart disease because diet helps to manage body cholesterol, triglyceride and fatty
acids, which minimizes the risk of cardiovascular arrest or attack. This review study
provided by Ress et al. (2013) is a best-suited example to study the impact of dietary
advice in chronic heart risk because 44 trials were reviewed in this study with both
individuals and groups as participants of the study. There were many interventions on
dietary management provided by professionals or dieticians. The study involves
analysis the impact each and every dietary intervention on the health of participants.
The variation in dietary intervention intensity is helpful to get best health results
4
develop a self-care attitude.
Part -2 Justification for selecting these references
Gorthi et al. (2014) review on different researches conducted to analyze the
impact of different Heart failure (HF) disease management programs (DMPs) can be
considered as a reliable source of information because the database is collected from
most authentic websites providing reliable information. This information about
hospital readmission DMPs can be used to manage the condition of Charlie because
he is confronting hospital readmission as an outcome of chronic heart failure he had 2
years before. Heidenreich et al. (2013) indicated that nursing interventions in
managing the chronic condition like heart failure, stroke, kidney disease, infection etc.
play a very important role to minimize the ruthlessness of that condition.
This review study can be considered as a reliable resource in terms of quality
because study data is collected from most reliable online websites. Secondly, the
methodology, sample researches and analysis tools are crucially analysed to gather
best possible outcomes. The review findings include the use of proper statistics that
provided most authentic outcomes. The review clearly mentions that the outcome
obtained about studied DMPs are not sufficient to determine the efficiency of HF
disease management program proves its reliability.
In the review different DMPs working on wide range of population are
compared to analyze the effect on hospital readmission after heart failure incidence.
Out of these DMPs, telemonitoring and structured telephone support are considered as
effective DMPs to control hospital readmission. These DMPs can be used as a part of
the nursing care plan to manage Charlie condition in provided case.
According to Yancy et al. (2013) studies diet is an important factor for chronic
heart disease because diet helps to manage body cholesterol, triglyceride and fatty
acids, which minimizes the risk of cardiovascular arrest or attack. This review study
provided by Ress et al. (2013) is a best-suited example to study the impact of dietary
advice in chronic heart risk because 44 trials were reviewed in this study with both
individuals and groups as participants of the study. There were many interventions on
dietary management provided by professionals or dieticians. The study involves
analysis the impact each and every dietary intervention on the health of participants.
The variation in dietary intervention intensity is helpful to get best health results
4
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because the impact of dietary intervention changes from person to person having
different body type (Aiken et al. 2014). Therefore, best intervention is detected by
such study because the intervention providing maximum positive response can be
considered as universally suitable for all body types (Stewart et al. 2012). This review
study provides this information about best suitable dietary intervention to control
chronic heart disease risk.
The study quality is refined, specific and reliable information sufficient for
provided case analysis. The study involves statistical analysis to get authentic and
measurable results understanding the impact of dietary change on cardiovascular risk.
The study involves each and every possible detail sufficient enough to implement it as
a beneficial reference resource in the study. This review analysis on dietary intake
shall help to manage the overweight condition of Charlie in provided case scenario.
According to Drewes et al. (2012) studies weight issues in old age people is a tough
task to handle along with other health risk conditions. This review is a very detailed
account of different dietary interventions and their impact on health. Therefore, this
review will work as a beneficial resource to manage the health condition of Charlie to
develop best nursing interventions related to weight management issues developing
chronic heart failure risk.
The nurse-led heart failure clinics improve survival and self-care behaviour
development study provided by Stromberg et al. (2003), is a proper scientific research
based on evidence to study the impact of nursing care on patient outcome. The study
is effective and accurate in terms of participating population, calculation tools and
statistical analysis providing strength and authenticity to findings. The quality of data
is impactful containing every bit of detail about research performed in the study.
However, the only limitation is the time duration of research, which is only 12
months.
Stamp, Machado & Allen (2014) indicated that 12 months is a very small
duration to analyze the long-term impact of lifetime condition life heart failure. In
contrast, Heidenreich et al. (2013) opine that a comparison between control group and
study group provides reliable results even in short duration time of any research.
Therefore, this study can be considered as a beneficial resource for developing
nursing interventions in provided case scenario. As Charlie in the present case is a 75-
year-old man requiring management of his chronic heart failure condition, this
research will help the involved nurse to develop best contemporary practices to
5
different body type (Aiken et al. 2014). Therefore, best intervention is detected by
such study because the intervention providing maximum positive response can be
considered as universally suitable for all body types (Stewart et al. 2012). This review
study provides this information about best suitable dietary intervention to control
chronic heart disease risk.
The study quality is refined, specific and reliable information sufficient for
provided case analysis. The study involves statistical analysis to get authentic and
measurable results understanding the impact of dietary change on cardiovascular risk.
The study involves each and every possible detail sufficient enough to implement it as
a beneficial reference resource in the study. This review analysis on dietary intake
shall help to manage the overweight condition of Charlie in provided case scenario.
According to Drewes et al. (2012) studies weight issues in old age people is a tough
task to handle along with other health risk conditions. This review is a very detailed
account of different dietary interventions and their impact on health. Therefore, this
review will work as a beneficial resource to manage the health condition of Charlie to
develop best nursing interventions related to weight management issues developing
chronic heart failure risk.
The nurse-led heart failure clinics improve survival and self-care behaviour
development study provided by Stromberg et al. (2003), is a proper scientific research
based on evidence to study the impact of nursing care on patient outcome. The study
is effective and accurate in terms of participating population, calculation tools and
statistical analysis providing strength and authenticity to findings. The quality of data
is impactful containing every bit of detail about research performed in the study.
However, the only limitation is the time duration of research, which is only 12
months.
Stamp, Machado & Allen (2014) indicated that 12 months is a very small
duration to analyze the long-term impact of lifetime condition life heart failure. In
contrast, Heidenreich et al. (2013) opine that a comparison between control group and
study group provides reliable results even in short duration time of any research.
Therefore, this study can be considered as a beneficial resource for developing
nursing interventions in provided case scenario. As Charlie in the present case is a 75-
year-old man requiring management of his chronic heart failure condition, this
research will help the involved nurse to develop best contemporary practices to
5
develop self-care behaviour for Charlie to manage his health condition at home.
PART -3. Recommendations for clinical practice
Chronic heart failure and its consequences remain a major health hazard to
contemporary people irrespective of significant management, care and treatments the
risk still remains high (Feltner et al. 2014). In the provide scenario, 75 years old Mr.
Charlie is also facing consequences of his chronic heart failure during his readmission
to hospital after 2 years of incidence. This indicates a lack of care interventions for
Mr. Charlie after his first chronic heart failure (Aiken et al. 2014). According to
Siouta et al. (2016) studies about multidisciplinary care principles for chronic heart
failure (CHF) that are used in Australia to provide high-quality nursing care. These
principles are the list of specific guidelines and strategies that can benefit patients
suffering CHF.
Further, Riegel, Jaarsma & Strömberg (2012) indicated that nutritional therapy
provided by nurses that involves sodium restriction in patient diet can help to control
pulmonary congestion. This intervention would help to manage the peripheral oedema
of Mr. Charlie. Radhakrishnan, Topaz & Creber (2014) studied about controlling
heart risk in old age patient where most workable interventions included managing
fluid intake, maintaining activity tolerance and establish a powerful connection with
the patient. This study would be beneficial to be used in the provided case because
Charlie is also an old age male suffering similar chronic condition.
6
PART -3. Recommendations for clinical practice
Chronic heart failure and its consequences remain a major health hazard to
contemporary people irrespective of significant management, care and treatments the
risk still remains high (Feltner et al. 2014). In the provide scenario, 75 years old Mr.
Charlie is also facing consequences of his chronic heart failure during his readmission
to hospital after 2 years of incidence. This indicates a lack of care interventions for
Mr. Charlie after his first chronic heart failure (Aiken et al. 2014). According to
Siouta et al. (2016) studies about multidisciplinary care principles for chronic heart
failure (CHF) that are used in Australia to provide high-quality nursing care. These
principles are the list of specific guidelines and strategies that can benefit patients
suffering CHF.
Further, Riegel, Jaarsma & Strömberg (2012) indicated that nutritional therapy
provided by nurses that involves sodium restriction in patient diet can help to control
pulmonary congestion. This intervention would help to manage the peripheral oedema
of Mr. Charlie. Radhakrishnan, Topaz & Creber (2014) studied about controlling
heart risk in old age patient where most workable interventions included managing
fluid intake, maintaining activity tolerance and establish a powerful connection with
the patient. This study would be beneficial to be used in the provided case because
Charlie is also an old age male suffering similar chronic condition.
6
References
Aiken, L. H., Sloane, D. M., Bruyneel, L., Van den Heede, K., Griffiths, P., Busse, R.,
... & McHugh, M. D. (2014). Nurse staffing and education and hospital mortality
in nine European countries: a retrospective observational study. The
Lancet, 383(9931), 1824-1830.
Drewes, H. W., Steuten, L. M., Lemmens, L. C., Baan, C. A., Boshuizen, H. C.,
Elissen, A. M., ... & Vrijhoef, H. J. (2012). The Effectiveness of Chronic Care
Management for Heart Failure: Meta‐Regression Analyses to Explain the
Heterogeneity in Outcomes. Health services research, 47(5), 1926-1959.
Feltner, C., Jones, C. D., Cené, C. W., Zheng, Z. J., Sueta, C. A., Coker-Schwimmer,
E. J., ... & Jonas, D. E. (2014). Transitional care interventions to prevent
readmissions for persons with heart failure: a systematic review and meta-
analysis. Annals of internal medicine, 160(11), 774-784.
Heidenreich, P. A., Albert, N. M., Allen, L. A., Bluemke, D. A., Butler, J., Fonarow,
G. C., ... & Nichol, G. (2013). Forecasting the impact of heart failure in the United
States: a policy statement from the American Heart Association. Circulation:
Heart Failure, 6(3), 606-619.
Radhakrishnan, K., Topaz, M., & Creber, R. M. (2014). Adapting heart failure
guidelines for nursing care in home health settings: challenges and solutions. The
Journal of cardiovascular nursing, 29(4), E1.
Riegel, B., Jaarsma, T., & Strömberg, A. (2012). A middle-range theory of self-care
of chronic illness. Advances in Nursing Science, 35(3), 194-204.
Siouta, N., van Beek, K., Preston, N., Hasselaar, J., Hughes, S., Payne, S., ... &
Hodiamont, F. (2016). Towards integration of palliative care in patients with
chronic heart failure and chronic obstructive pulmonary disease: a systematic
literature review of European guidelines and pathways. BMC palliative care, 15(1),
18.
Stamp, K. D., Machado, M. A., & Allen, N. A. (2014). Transitional care programs
improve outcomes for heart failure patients: an integrative review. Journal of
Cardiovascular Nursing, 29(2), 140-154.
Stewart, S., Carrington, M. J., Marwick, T. H., Davidson, P. M., Macdonald, P.,
Horowitz, J. D., ... & Scuffham, P. A. (2012). Impact of home versus clinic-based
7
Aiken, L. H., Sloane, D. M., Bruyneel, L., Van den Heede, K., Griffiths, P., Busse, R.,
... & McHugh, M. D. (2014). Nurse staffing and education and hospital mortality
in nine European countries: a retrospective observational study. The
Lancet, 383(9931), 1824-1830.
Drewes, H. W., Steuten, L. M., Lemmens, L. C., Baan, C. A., Boshuizen, H. C.,
Elissen, A. M., ... & Vrijhoef, H. J. (2012). The Effectiveness of Chronic Care
Management for Heart Failure: Meta‐Regression Analyses to Explain the
Heterogeneity in Outcomes. Health services research, 47(5), 1926-1959.
Feltner, C., Jones, C. D., Cené, C. W., Zheng, Z. J., Sueta, C. A., Coker-Schwimmer,
E. J., ... & Jonas, D. E. (2014). Transitional care interventions to prevent
readmissions for persons with heart failure: a systematic review and meta-
analysis. Annals of internal medicine, 160(11), 774-784.
Heidenreich, P. A., Albert, N. M., Allen, L. A., Bluemke, D. A., Butler, J., Fonarow,
G. C., ... & Nichol, G. (2013). Forecasting the impact of heart failure in the United
States: a policy statement from the American Heart Association. Circulation:
Heart Failure, 6(3), 606-619.
Radhakrishnan, K., Topaz, M., & Creber, R. M. (2014). Adapting heart failure
guidelines for nursing care in home health settings: challenges and solutions. The
Journal of cardiovascular nursing, 29(4), E1.
Riegel, B., Jaarsma, T., & Strömberg, A. (2012). A middle-range theory of self-care
of chronic illness. Advances in Nursing Science, 35(3), 194-204.
Siouta, N., van Beek, K., Preston, N., Hasselaar, J., Hughes, S., Payne, S., ... &
Hodiamont, F. (2016). Towards integration of palliative care in patients with
chronic heart failure and chronic obstructive pulmonary disease: a systematic
literature review of European guidelines and pathways. BMC palliative care, 15(1),
18.
Stamp, K. D., Machado, M. A., & Allen, N. A. (2014). Transitional care programs
improve outcomes for heart failure patients: an integrative review. Journal of
Cardiovascular Nursing, 29(2), 140-154.
Stewart, S., Carrington, M. J., Marwick, T. H., Davidson, P. M., Macdonald, P.,
Horowitz, J. D., ... & Scuffham, P. A. (2012). Impact of home versus clinic-based
7
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management of chronic heart failure: the WHICH?(Which Heart Failure
Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital
Care) multicenter, randomized trial. Journal of the American College of
Cardiology, 60(14), 1239-1248.
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., ... &
Johnson, M. R. (2013). 2013 ACCF/AHA guideline for the management of heart
failure: executive summary: a report of the American College of Cardiology
Foundation/American Heart Association Task Force on practice
guidelines. Journal of the American College of Cardiology, 62(16), 1495-1539.
8
Intervention Is Most Cost-Effective & Consumer Friendly in Reducing Hospital
Care) multicenter, randomized trial. Journal of the American College of
Cardiology, 60(14), 1239-1248.
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., ... &
Johnson, M. R. (2013). 2013 ACCF/AHA guideline for the management of heart
failure: executive summary: a report of the American College of Cardiology
Foundation/American Heart Association Task Force on practice
guidelines. Journal of the American College of Cardiology, 62(16), 1495-1539.
8
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