This summary discusses the four classes of hypoglycemic drugs for type 2 diabetes treatment: Sulfonylureas, Metformin, Thiazolidinediones, and Alpha-glucosidase inhibitors. It explains their mode of action, side effects, and drug interactions. The pharmacological treatment of diabetes is associated with several side effects and drug interactions. Hence, adherence to a suitable diet and physical exercise are still considered to be most effective, and these drugs are only approved for those not responding to diet, exercise, and weight reduction.