This presentation explores the profound impact of significant life events, both normative and non-normative, on individuals at various stages of life. It delves into the specific case of Down syndrome, examining its effects on individuals and their social networks across childhood, adolescence, adulthood, and older age. The presentation also discusses the responses of groups and societies to such events, highlighting the potential for both positive and negative impacts on the affected individual's well-being. Finally, it emphasizes the crucial role of health and social care professionals in providing support and understanding to individuals experiencing significant life events, particularly those with Down syndrome.