The provided document is an analysis of environmental factors influencing cancer treatment. It includes a list of references to relevant research papers on topics such as tumor micro-environment heterogeneity, internal environment analysis, and the use of the wiseboard model in hospital settings. The assignment also provides summaries of articles discussing the influence of tumor micro-environment on therapeutic response, the role of HGF secretion in innate resistance to RAF inhibitors, and the importance of Wnt activity in defining colon cancer stem cells.