Impact of Impaired Lipoprotein Metabolism on CHD Risk

LIPOPROTEIN
ESSAY

Table of Contents
INTRODUCTION...........................................................................................................................1
MAIN BODY...................................................................................................................................1
Impact of impaired lipoprotein metabolism on CHD risk......................................................1
Impact of considered dietary modifications on blood lipid concentration.............................4
Impact of considered dietary modification on lipoprotein metabolism and thus mechanisms
responsible for changes in blood lipids and CHD risk...........................................................7
CONCLUSION................................................................................................................................9
REFERENCES..............................................................................................................................10
Books and Journals ..............................................................................................................10

INTRODUCTION
Lipoprotein is defined as the substance which is contain lipid that is also called fat and
protein. They are soluble complexes in nature as like yolk and mammalian blood plasma and
insoluble one as in cell membrane. Lipoprotein have vital role in the development of body and
they perform various function. In this, lipoprotein in blood plasma have studied because they
mode of transport for cholesterol as per follow the path of blood stream and lymphatic fluid. As
per this report, the role of lipoprotein in body function are discussed. The impact of impaired
lipoprotein metabolism which is reflected in blood concentration on coronary heart disease. In
this, the impact of dietary modification on blood lipid concentration (Asztalos and et. al., 2019).
MAIN BODY
Impact of impaired lipoprotein metabolism on CHD risk
Cardiovascular disease are the dominant single disease which is occur now day in very
rapid mode. There are mortality rate from this disease is more than other disease. As per this, the
coronary heart disease have more causes of death and 5 percent death are recorded due to stroke.
The pathological condition of coronary heart disease is atherosclerosis. This create obstruction in
vessel as per this blood does not flow properly and create complication. In this, due to coronary
heart disease several of risk factor is associated with this and this is called as casual factor. Some
of causal factor which is mentioned are cholesterol and other lipid abnormalities, elevated blood
pressure, smoking, diabetes, blood coagulation and many more factor. The main impact which is
formulated coronary heart disease is excess cholesterol and lipoprotein and their impaired
metabolism in body. Fat such as cholesterol and triglycerides are transported in the blood as the
core part of lipoprotein particle. The lipoprotein have various part such as low density lipoprotein
which is responsible for carrying proper and more blood cholesterol. Very low density
lipoprotein which carry blood triglycerides and high density lipoprotein and chylomicrons which
help in absorption of fat.
1

The excess LDL cholesterol that is total serum cholesterol which is more than 4 to 5 mole
per litre is accepted the risk factor with heart disease. Excess triglycerides which is more than 1.8
mole per litre are major required in coronary heart disease but this create an controversial
statement. The low concentration of high density level cholesterol which is less than 1.0 mole
per litre which accept the major risk factor which is associated with this. In this context, the
triglycerides is more important when the level of High density lipoprotein cholesterol is low in
number (Dentali and et. al., 2017). As per this, the balance of total high density lipoprotein
cholesterol is major chance and there are various ratio from the total high density lipoprotein per
high density lipoprotein. The values are estimated which is more than 4 to 5 for ratio which may
be adverse but use of this kind of ratio is controversial. In addition, the serum cholesterol has
number of significant risk factor which is associated with coronary heart disease and also with
various cardiovascular diseases.
2
Illustration 1: Lipoprotein