NURSING NSC2500 Assignment: The Drug Glibenclamide

Running head: NURSING
NSC2500
Name of the Student
Name of the University
Author Note

1NURSING
Abstract
Introduction- Type 2 diabetes mellitus comprises of a plethora of dysfunctions that are
predominantly characterized by hyperglycaemia. They are caused due to a combination of
insufficient secretion of insulin, and resistance to action of the insulin hormone. Majority of the
patients diagnosed with type 2 diabetes are asymptomatic, and their clinical manifestations
comprise of blurred vision, weight loss, polyphagia, polydipsia, and polyuria.
Summary- The drug glibenclamide belongs to the class of sulfonylurea and is administered for
the management of type 2 diabetes. It is generally recommended along with other dietary
modifications and physical activity. It is also recommended in conjunction with other
antidiabetic medications like metformin. However, the drug is typically not recommended for
individuals who are diagnosed with type 1 diabetes mellitus. Its route of administration is
primarily through the mouth. Common side effects of this drug are heartburn and nausea. Serious
side effects might result in low blood sugar and angioedema. Though it is not recommended at
the time of pregnancy, but can be administered during breastfeeding.
Target audience- Australian adults aged more than 40 years who have been diagnosed with type
2 diabetes mellitus are the target audience for this lay article. This can be accredited to the
prevalence of the metabolic condition in the nation, and the lifestyle factors that make Australian
adults susceptible to type 2 diabetes.
Conclusion- It can be concluded that if the nursing professionals administer the drug
glibenclamide to the target population, they would observe an effective reduction in high blood
glucose levels.
Keywords: type 2 diabetes mellitus, glibenclamide, Australia

2NURSING
Table of Contents
Homeostasis.....................................................................................................................................3
Pathophysiology..............................................................................................................................3
Pharmacology..................................................................................................................................5
Drug name...................................................................................................................................5
Pharmacodynamics......................................................................................................................5
Pharmacokinetics.........................................................................................................................6
Route of Administration..............................................................................................................6
Indications contraindications precautions and side effects..........................................................7
Drug interactions.............................................................................................................................7
Lifestyle modification......................................................................................................................8
Relevance to clinical practice..........................................................................................................8
Conclusion.......................................................................................................................................8

3NURSING
Homeostasis
The endocrine system has been found to play a significant role in controlling homeostasis
in the human body, due to the action of hormones that help in regulating activity of different
tissues and cells, located in the body. The endocrine system controls the release of hormones in
circulating bloodstream by means of a stimulus. Presence of a stimulus either leads to an increase
or decrease in the secretion of a particular hormone. As a response to a change in stimulus, there
occur variations in the internal state of the body (Hall, 2016). It is commonly referred to as
feedback regulation and encompasses a self adjusting mechanism. Feedback regulation generally
arises when the response of the body to a certain stimulus creates an impact on the originals
stimulus. While negative feedback happens when the original stimulus is reduced due to the
response, positive feedback takes place upon augmentation of original stimulus due to the
response.
Pathophysiology
Type 2 diabetes is also referred to as adult onset diabetes, and refers to a metabolic
syndrome that is predominantly characterized by insulin resistance, high amount of blood sugar,
and comparative lack of insulin hormone in the body. Some of the common signs and symptoms
of this condition include increased thirst, increased hunger, frequent urination, and unexplained
loss of body weight (Zaccardi et al., 2016). Type 2 diabetes can be accredited to inadequate
production of insulin hormone from the beta cells that are located in the Islets of
Langerhans. This results in a pathological condition that is characterized by failure of the cells to
appropriately respond to the hormone insulin. This in turn causes insulin resistance.