This nursing assignment is based on the case study of Mr Frank Wright, a 76 years old man who has undergone total replacement surgery of the right knee. The paper will focus on the three nursing priorities within first 24 hours of surgery. Mainly in the first part of the assignment, post-surgical plan will be illustrated with the help of clinical reasoning cycle. The second part of the assignment will cover the complication that must be associated with pathophysiology of obstructive sleep apnoea and smoking and how it affects post-surgical recovery and during general anaesthesia. This part will also focus on co-morbidities associated with smoking and obstructive sleep apnea and nursing interventions to overcome those complications. The third part of the assignment will discuss the discharge planning of the patient, Mr Wright following the total knee replacement surgery.