Research on Resistance of Silver to Antibiotics

Running head: Research on resistance of silver to antibiotics
Research on resistance of silver to antibiotics
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RESEARCH ON RESISTANCE OF SILVER TO ANTIBIOTICS1
Table of Contents
Abstract......................................................................................................................................2
Importance of the research:........................................................................................................2
Background................................................................................................................................4
Previous studies..........................................................................................................................6
References..................................................................................................................................8

RESEARCH ON RESISTANCE OF SILVER TO ANTIBIOTICS2
Abstract
The model studies of the peptide bonds shows that the silver resistance protein SilE
coordinates with Ag+ ion, which is known for their bacterial resistance properties
(Mijnendonckx et al., 2013). The resistance can be mostly seen in gram-negative bacteria like
S. typhimurium due to their genetic mutations. Methionine and histidine is also involved in
silver ion coordination. The study focusses on the exogenous and endogenous resistance to
silver. The sil operon contains nine structural genes and thorough studies showed the
functions of SilE only, which is a periplasmic silver binding protein. Endogenous and
mutational studies conducted in laboratory reported significantly in negative bacteria.
Importance of the research:
. Colloidal silver claimed to be in use for cure of illness like HIV or certain infections
is actually not good for use and sometimes prove to be fatal. This kind of resistance to
antibiotics needs more emphasis of study otherwise would make us vulnerable to known and
unknown diseases (Finley et al., 2013). Bacterial genetic diversity is the cause of concern for
the resistance. Antibiotic resistance is fast prevailing as a threat to health of everyone
irrespective of age or country.
Antibiotics need to develop latest machinery to combat the resistance of bacteria.
Silver has a property of antimicrobial, which is used, in boosting the action of antibiotics.
Silver sulfadiazine is the compound found in silver having medical use (Mijnendonckx et al.,
2013). The increasing use of silver in medical and non-medical is posing threat to bacterial
resistance thus posing resistance to antibiotics. Understanding SilE, which is a form of
protein, would give an insight into machinery of the bacteria and main cause of resistance.
This issue needs to be addressed well as this may lead to therapeutic failure.