( 7304MED)-Assessing the Efficacy of Preexposure Prophylaxis (PrEP) in Preventing HIV: Key Findings and Analysis

In this report we will discuss about health care systems and below are the summaries point:- The main thesis of the paper is to assess the effectiveness of preexposure prophylaxis (PrEP) in preventing HIV transmission and identify factors influencing its adoption. The main findings indicate that PrEP usage consistently reduces HIV seroconversion cases, discontinuation is not due to renal toxicity but related to insurance coverage and race factors. The accuracy of the paper is ensured through the use of statistical methods, detailed participant analysis, and categorization, providing reliable measurements. The validity of the results is supported by real-world data collection, similar outcomes to previous studies, and statistical inference validation.

7304MED HEALTH CARE SYSTEMS - READING LOG TEMPLATE
Student Name:
Student Number:
Criterion Response to Criterion
Correct Citation (in
APA6 format)
Marcus, J. L., Hurley, L. B., Hare, C. B.,
Nguyen, D. P., Phengrasamy, T.,
Silverberg, M. J., ... & Volk, J. E.
(2016). Preexposure prophylaxis for
HIV prevention in a large integrated
health care system: adherence, renal
safety, and discontinuation. Journal
of acquired immune deficiency
syndromes (1999), 73(5), 540.
McCormack, S., Dunn, D. T., Desai, M.,
Dolling, D. I., Gafos, M., Gilson, R., ...
& Mackie, N. (2016). Pre-exposure
prophylaxis to prevent the
acquisition of HIV-1 infection
(PROUD): effectiveness results from
the pilot phase of a pragmatic open-
label randomised trial. The
Lancet, 387(10013), 53-60.
What is the main
thesis of the paper
The objective of the paper is to identify
the efficacy of preexposure prophylaxis
(PrEP) in preventing HIV, based on
associated factors that motivate patient to
adopt PrEP (Marcus et al., 2016).
What are the main
findings of the
work?
PrEP usage have consistent effect in
reducing HIV seroconversion cases.
Discontinuation of PrEP is not due to renal
toxicity, but because of loss of insurance
coverage and specific race of Blacks, and
among drug abuse disorder people.
How are you
assured of accuracy
within the paper
The results are based on 850 person-years
of PrEP and clinical outcomes are
measured before and after PrEP. The
analysis are based on sex, ethnicity,

Criterion Response to Criterion
clinical consideration, and results were
concluded with identification of HIV
seroconversion cases. The complete
analytical details including number of
participants and their categorization
details, assure the accuracy within the
paper.
How are you
assured of
Reliability of the
measurements
used in the paper
The clinical outcomes were assessed using
statistical methods having level of
confidence 0.005 or alpha value < 0.001,
which assured the reliability of
measurements.
How are you
assured of the
Validity of the
results
Clinical results of PrEP adherence were
known, which motivates the author to
collect real-world data (McCormack et al.,
2016). The results were similar that PrEP
prevent HIV seroconversion with minimal
renal toxicity. Moreover, the results were
validated with statistical inference.
Can the findings be
generalized to the
wider community?
The findings are important for:
implementing change in guidelines for STI
screening, black people and women are
required to provide education about PrEP
importance, and social factors like
insurance coverage issues that is
responsible for discontinuation must be
resolved.
Describe what you
agree with and/or
what you disagree
with in the paper.
Agree: PrEP is useful in controlling HIV
infection.
Disagree: The long term usage must be
tested, which can confirmed the time-
period upto which PrEP is effective in
preventing HIV seroconversion. Hence,
mere finding that PrEP control HIV, is not
sufficient, rather duration of efficiency is
also important.
How useful (or not) The paper is useful because PrEP usage

Criterion Response to Criterion
was the paper and
why have you
reached this
conclusion?
can be recommended in community
health programs. The paper was selected
because it shed light on the efficacy of HIV
prophylactic drugs and associated side
effects.
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