Pathogenesis and Clinical Manifestations of Asthma in Peter

Short answer questions

TABLE OF CONTENTS
QUESTION 1..................................................................................................................................3
QUESTION 2..................................................................................................................................4
QUESTION 3..................................................................................................................................5
REFERENCES................................................................................................................................7

QUESTION 1
Pathogenesis which caused clinical manifestations presented by Peter
As observed in the case in Peter, the respiratory symptoms were seen along with not able
to speak full sentences continuously. These symptoms could be because of his overweight at a
very tender age and also due to the fact that he was diagnosed with Asthma. The pathogenesis is
basically the process which is responsible for developing the disease or the disorder. These
involve the factors which lead to the onset of the disease and also cause its progression and
maintenance (Gon and Hashimoto, 2018). Asthma is considered as the common chronic
disease across the world which is affecting more than 26 million people in Australia like Peter.
In childhood, this is becoming the most common chronic disease which affected more than 7
million children. The pathophysiology of asthma is considered to be complex and also includes
intermittent airflow obstruction, inflammation and bronchial hyper-responsiveness.
The pathogenesis of asthma can be described as the presentation of antigen by the dendritic cell
along with the cytokine and lymphocyte response which leads to the airway inflammation and
the symptoms of asthma. During
the episode of asthma, the airways which are inflamed react to the triggers in the environment
like dust, smoke or pollen. There is narrowing of the airways and production of excess mucus
which makes difficulty in breathing. This is why, asthma is considered as the result of the
response which has on the bronchial airways. Peter also was diagnosed with Asthma which is
why the pathogenesis of the Asthma is described. This is considered as the chronic inflammatory
disorder of the airways which makes the implications of Asthma as diagnosing, managing and
preventing of the disease (Russell and Brightling, 2017). The inflammatory cell infiltration is
included in the immunohistopathologic features such as eosinophils, neutrophils, lymphocytes
etc. The airway inflammation can also contribute in the airflow limitation, disease chronicity,
respiratory symptoms and airway hyperresponsiveness. The gene-by-environment interactions
also play a major role in the asthma expression. There is an interaction between the host factors
and the environmental exposures which occurs when the immune system is developed.
3