Type 1 Diabetes: Risk Factors, Aetiology, Pathophysiology, Clinical Manifestations, Diagnostic Tests, and Treatment

5% genetic susceptibility
Geographical contributor
Impact on
immune
system
Insulin production halts
Pathophysiology
Risk Factors
Aetiology
Clinical
manifestations
Diagnostic tests
Treatment
Stay in
Finland
T1D in father
Innate immune
system activated Weight loss
Family history and
environmental factors
polyuria
Insulin injections
Anti-CD3 antibodies
Beta cells of pancreas are
destroyed
Autoimmune response
HLA genetics
HLA-DQA1, HLA-DQB1, and
HLA-DRB1 genes
Excessive hunger
and thirst
expansion of CD4+
and CD8+T cells
Tonsillecto
my and
Celiac
disease
Exercise for maintaining
body weight
Carbohydrate, protein and fat
counting
Frequent blood-
glucose
monitoring
Dietary modifications
polydipsia
Immune system attack cells
of own body
Glycated haemoglobin
tests
Key
Self-management
education
Laboured breathing

750 words explanation
Type 1 diabetes refers to an autoimmune condition that is characterised by activation of the immune system to kills or destroy beta cells in the pancreas, the primary role
of which is to produce insulin hormone (Atkinson, Eisenbarth&Michels, 2014). An analysis of the case study suggests that the major risk factor that accounted for the metabolic disease in
Emilia, is the presence of the disorder in her father. Research evidences have established the genetic association of T1D and also suggest that the risk of a child for developing the condition
is an estimated 5%, if it is present in the father and about 8% and 3%, if found in a sibling or the mother, respectively (Pociot&Lernmark, 2016). Furthermore, Caucasians residing in
different regions of the Europe are more vulnerable to the disorder (Ma & Chan, 2013). This can be considered as a major risk factor since Emilia was born in Finland and stayed there
during her childhood. In addition, Celiac disease (CD) and T1D share some common susceptibility factors, primarily HLA genetics, such as, HLA-DQA1, HLA-DQB1, and HLA-DRB1 genes that
play a crucial role immune system functioning (Lionetti et al., 2014). Furthermore, studies have also illustrated the fact that adenoidectomy and tonsillectomy in childhood create an impact
on the functioning of the immune system and increase the likelihood of a child to suffer from T1D. (Cadario et al., 2017) The surgery activates an autoimmune reaction that results in the
immune system attacking cells of its own body, thereby destroying the beta-cells of islets of Langerhans and impeding production of insulin ( Blumenfeld, 2016). Hence, the primary reasons
that might have contributed to the development of type 1 diabetes in Emilia are presence of the disease in her father, her stay at Europe, and history of tonsillectomy and celiac disease.
The pathophysiology of T1D involves destruction of the beta cells of the pancreas, regardless of the causative entity or risk factor that might have contributed to the
disease. Autoimmune response towards the beta cells of the islets of Langerhans is the primary manifestation of the condition and generally involved an expansion of CD4+ and CD8+T
helper cells that are autoreactive in nature, in addition to activating the innate immune system (Sarikonda et al., 2014). One common symptom that arises as a result of this
pathophysiology is drastic weight loss (Chiang, Kirkman, Laffel&Peters, 2014). The symptom of polyuria or frequent urination was exhibited by Emilia, as evident by the reports of excessive
urination. Furthermore, her physical examination revealed weight loss, and rapid breathing.