This report discusses the importance of information system security (ISS) in small and medium-sized enterprises (SAME) and proposes a methodology to establish a safe and secure working environment. The report covers ISS initiatives, possible threats, and solutions, including accidental data corruption, loss of intellectual property, theft of information from hackers and employees, web site defacement, and software piracy. The report concludes that SAME must adopt information system safety as a standard step in their routine work management process to create a safe work environment.