HEALTH SCIENCES 2Describe how the pathological changes in Osteoarthritis relate to the clinicalmanifestations of the DisorderOsteoarthritis (OA is characterized as a type of arthritis that majorly affect the joint tissues of the body and at times causes the swelling on those areas. The most affected joints are knee, finger, neck, and waist. It is observed to be the primary cause of disability among the agedpeople. The high prevalence of OA is most common among the obese people. Therefore, it is ideal to understand the pathophysiology of OA to identify some of the mechanism such as treatment to decrease the sensitivity of the condition. Nevertheless, it is imperative to underscorethat the disease may affect any joint tissue in the body and thus it is not primarily targeting only a particular section of the body. There are pathological changes that are observed in the OA showing some significant variations in the early stages of it. The emerging of magnetic resonance imaging (MRI) has significantly aided in the pathophysiology of OA and the detectionof joint tissues condition. Some researchers reveal that subchondral bone is crucial in OA and thereby it is present during the remodeling of the bone. From the surgical specimens, it is evidentthat a person with OA exhibits some form of attrition in the subchondral bone that is flattening and does not have the direct relation with the fracture (Blaker, Zaki, Clarke & Little). The MRI indicates some notable changes in the subchondral bone such as increment in volume and its thickness and thus weakening the minerals in those areas as compared to the healthy bone. There is increased the force of transmission through the joints that are caused by dissipation energy around the subchondral. It is incumbent to note that some animal models are used in demonstrating the cartilage lesion in respect to subchondral bone damage (Shirley & Hunter).Further research indicates that the pain in the human joint is commensurate to the increasing turnover in the subchondral bone.

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