Importance of Protein Binding in Clinical Drug Development

Importance of
protein binding in
clinical drug
developmentNAME OF THE STUDENT
NAME OF THE UNIVERSITY
AUTHOR NOTE:

Protein in microbes
 Microbial proteins defines as the
protein requires for conducting
normal process of cell.
 The proteins also include the
normal cellular protein resembles
to the human to conduct normal
body cycle and proteins require
for the surviving in the host (4).
 examples , endotoxins,
exotoxins, leucocidine, plasma
protein, hymolysin
Figure: bacterial
protein
SOURCES: 6

FUNCTION OF MICROBIAL
PROTEIN
 The function of the
microbial protein is to
help in metabolism.
 To collect food from
other sources
 assist in cell division(3)
 to bind to the host
 survive inside the host
Figure: bacterial
protein
SOURCES

IMPORTANCE OF MICROBIAL PROTEIN
BINDING IN DRUG DEVELOPMENT
 A considerate number of antimicrobial
drug such as antibacterial drug target
extracellular or intracellular protein of the
bacteria to inhibit or static the growth of
bacteria
 The protein binding of bacteria also help
in reduction of deadly infections, assist in
evaluating the resistant mechanism of
bacteria which further showed the
direction of future research.
Figure: bacterial
protein
SOURCES: 7

antimicrobials
 Antimicrobials defined as a substance that either kills or
inhibits the growth of microorganism such as bacteria,
fungi and protozoa 8)
history:
in previous era various molds and plant extracts were used
to treat infections by some of the earliest civilisations such as
ancient Egyptians
After deaths of millions of individuals because of infections
such as such as pneumonia and diarrhea. Paul Ehrlich , the
German physicians suggested that certain chemical dyes
colored have ability to kill bacteria. Later, Alexander
Fleming worked on Penicillium notatum and accidentally
discovered penicillin.
Figure:
antimicrobials
SOURCES: 7

History of antibiotics
Figure: History of antibiotics
SOURCES: 7

Protein target for antibacterial
drug development
 The potential drug target for antimicrobial
proteins
Bacterial
surface
protein
Bacterial
intracellular
proteins
lipoproteins
Trans
membrane
protein
Porin
proteins
DNA
polymerase
DNA
Gyrase

Key point of drug targets in
clinical development
 It should give have maximum drug effect
 It should not cause side effects in body
 it should be readily soluble in the body
 it should not target human proteins (9)
 it should not destroy by metabolic fluids of
human body(8)
 it should readily thatched to the bacterial
protein4
 it should have bacteriostatic or bactericidal
property
Figure: bacterial
protein
SOURCES: 7