Nano pill as novel drug delivery system

Running head: ENGINEERING RESEARCH PROPOSAL
ENGINEERING RESEARCH PROPOSAL
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ENGINEERING RESEARCH PROPOSAL1
Nano pill as novel drug delivery system
Summary of proposal
The pharmaceutical companies are more prone to use chemical-based drug delivery
system rather than investing in a natural product-based system. The significant concerns
related to natural products are biocompatibility and toxicity because of which they do not
pass the clinical trial phases. Moreover, the large size poses a significant challenge in the
effective delivery of the drug in the body; thus, the investigation of new and novel drug
delivery system was done. Nanotechnology plays an essential role in drug formulation or
advanced medicines that is thought to release the drug in a controlled and effective manner
with a high rate of success (Patra et al., 2018). The research aims to evaluate the efficacy and
effectiveness of Nano pill as a novel and unique drug delivery system. Various studies have
been used that highlighted the importance of nanotechnology in the arena of specific
targeting of the drug in a controlled and effective manner. Gangwar et al. (2015) opined that
the application of nanotechnology forms a bridge between the physical and biological science
in using Nano phases and nanostructures in different fields of science, especially in case of
Nanomedicine and Nano-based drug delivery system. The use of secondary resources will be
conducted that will support in investigating the beneficial aspects of Nano pills as an
effective drug delivery system in the modern time because it allows targeted and control
delivery of the drug in the body.
Introduction
From ancient time, humans have used plant-based products as medicines for treating
different diseases. The modern medications are based on the traditional knowledge and
practices of different herbs, where 25% of the compounds available are obtained from natural
products. According to Lombardo, Kiselev and Caccamo (2019), natural products

ENGINEERING RESEARCH PROPOSAL2
demonstrate various features such as chemical diversity, less toxicity, biological and
chemical properties with macromolecular specificity. The molecular interaction of these
drugs helps in appropriate drug delivery. However, in recent times, a number of challenges
related to these products were identified. According to Tariq, Bhawani and Moheman (2019),
the challenges included poor solubility, bioavailability, the large size of the products, poor
absorption, less specificity, issue related to tonic effectiveness and other adverse impacts.
Thus, scientists have formulated Nano pills that can be used to mitigate the issues. As per the
study of Rizvi and Saleh (2018), Nano drugs are submicron-sized therapeutic agents that can
be adsorbed, dispersed or covalently bounded in a compressed vesicle or matrix form to
deliver a limited amount of drug in a target location. This is also known as Nano drug
enabled technology that allows employing drugs to specific types of cells such as cancer
cells. Ventola (2017) stated that this is effective in nature because it reduces the damage of
normal and healthy cells in the body as well as identification of disease in an early manner.
Thus, it is thought to help in extending the lives of human by eradication of life-threatening
diseases that include cancer and support in repairing the damage caused in the body at the
cellular level.
Literature review and recent progress
According to Zarekar, Lingayat and Pande (2017), Nano gels are one of the popular
techniques in the nanotechnology that demonstrated success in drug delivery in the body. The
Nanoparticle framework used materials less than 100 nm that was bounded using crosslinking
bonds. The advantage of Nano gels includes high medication loading limit, biodegradability,
biocompatibility that effectively adequately delivered drugs. The advancement in Nano gel
involves developments of different types of gels using the synthetic process of drug delivery
mechanism that allowed in offering treatment to various diseases. Even though extensive
researches have been conducted on cancer, however, the overall survival rate is poor.

ENGINEERING RESEARCH PROPOSAL3
According to Da Silva et al. (2016), the use of cancer chemotherapy and anticancer
immunotherapy can be used for treating the disease. In the upcoming years, a multitude of
new chemotherapy agents will be accessible that will efficiently treat the tumour cells and
support antigen exposure. The use of Nano vehicles is referred to as therapeutic agents that
are biocompatible in nature and is stated to be a potential candidate for targeted drug delivery
in treating different types of cancers. A deadly combination of Nanotechnology,
chemotherapeutic engineering and cancer immunotherapy can be collated to form a targeted
cancer therapy that helps in early detection and treatment of cancer. A study conducted by
Koushik et al. (2016) opined that the evolving treatment form had to highlight Nanomedicine
as an alternative drug delivery system. It is responsible for limiting the side effects on the
healthy tissue in the body and help in the progression of the efficacy of the treatment process.
Over the years, it can be seen that resistance of cancer drug treatment is stated to be a
complicated process that involves various mechanisms. To address the issue and
complications that lead to the development of new possibilities in term of Nanomedicines.
This is one of the new prospects of cancer treatment that can be used as drug delivery an
advanced design that is proved to be useful in limiting the resistance posed in various cancer
drug delivery system. In a similar study conducted by Hare et al. (2017), advances in drug
delivery technologies have focused on different areas of oncology where strategies related to
Nanomedicines development need to be applied. The success rate of this technology is
because of the small size that helps in targeting the drug in specific locations, thus, improving
the decision-making framework, including AstraZeneca’s 5R Principle. This enhances the
translation and performance of Nanomedicines using a data package for assimilating more
information related to the new and novel drug delivery system. Linko, Ora and Kostiainen
(2015) stated that DNA molecules could be accumulated in a customised pre-designed shape
with the help of hybridization through sequence-complementary domains. These shapes have