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Pharmacology and Pathophysiology Assignment

   

Added on  2021-05-31

4 Pages716 Words49 Views
Pharmacology and Pathophysiology 1Pharmacology and PathophysiologyBy Student’s NameCourse + CodeClassInstitutionDate
Pharmacology and Pathophysiology Assignment_1
Pharmacology and Pathophysiology 2AbstractIntroductionThe Alzheimer’s disease involves a decrease in memories. The synaptic loss is usually the major defects in the memory loss(Hsu, Lane and Lin, 2018). Calcium ions play a major role in signaling abnormalities mostly by affecting the endoplasmic reticulum. The Familial Alzheimer’s disease mutations in the presenilins are directly linked endoplasmic reticulum calcium ions leaked function presenilins(Amidfar, Kim and Wiborg, 2018). As a result, calcium ions dysregulation is involved in Alzheimer's disease(Popugaeva, Vlasova and Bezprozvanny, 2015). Various amyloid proteins have been proved to be involved in the induction of calcium ions influx into neurons, making this calcium reflux alters neurological excitability(Hsu, Lane and Lin, 2018). In that case, therefore, calcium ions might be the key to the step of studying the pathogenesis of Alzheimer's disease(Popugaeva, Pchitskaya and Bezprozvanny, 2017).Key pointsCalcium ions are involved in abnormalities affecting the endoplasmic reticulum. The delayed calcium ions signaling in the in the synaptic loss may be the key reason for the pathogenesis of Alzheimer disease(Popugaeva, Pchitskaya and Bezprozvanny, 2017). Calcium ions normally target the synaptic calcium signaling pathways which mayoffer a pathway for development of other Alzheimer's disease medications(Dyer etal., 2017).However, there are various drugs used in the treatment of the disease namely Cholinesterase inhibitors and memantine(Alzheimer's Association, 2018).
Pharmacology and Pathophysiology Assignment_2

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