Pharmacology and Pathophysiology Assignment

Added on - 31 May 2021

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Pharmacology and Pathophysiology1Pharmacology and PathophysiologyBy Student’s NameCourse + CodeClassInstitutionDate
Pharmacology and Pathophysiology2AbstractIntroductionThe Alzheimer’s disease involves a decrease in memories. The synaptic loss isusually the major defects in the memory loss(Hsu, Lane and Lin, 2018). Calcium ions playa major role in signaling abnormalities mostly by affecting the endoplasmic reticulum.The Familial Alzheimer’s disease mutations in the presenilins are directly linkedendoplasmic reticulum calcium ions leaked function presenilins(Amidfar, Kim and Wiborg,2018). As a result, calcium ions dysregulation is involved in Alzheimer'sdisease(Popugaeva, Vlasova and Bezprozvanny, 2015). Various amyloid proteins have beenproved to be involved in the induction of calcium ions influx into neurons, making thiscalcium reflux alters neurological excitability(Hsu, Lane and Lin, 2018). In that case,therefore, calcium ions might be the key to the step of studying the pathogenesis ofAlzheimer's disease(Popugaeva, Pchitskaya and Bezprozvanny, 2017).Key pointsCalcium ions are involved in abnormalities affecting the endoplasmic reticulum.The delayed calcium ions signaling in the in the synaptic loss may be the keyreason for the pathogenesis of Alzheimer disease(Popugaeva, Pchitskaya andBezprozvanny, 2017).Calcium ions normally target the synaptic calcium signaling pathways which mayoffer a pathway for development of other Alzheimer's disease medications(Dyer etal., 2017).However, there are various drugs used in the treatment of the disease namelyCholinesteraseinhibitors and memantine(Alzheimer's Association, 2018).
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