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The Effect of Calcium in Patient with Alzheimer Disease

   

Added on  2021-05-30

17 Pages1300 Words42 Views
ALZHEIMER'S DISEASE PHARMACOTHERAPY AND CA2+ INVOLVEMENT

Calcium as a regulatory and signalling ionCalcium ions can act as neurotransmitters signals either directly or indirectly(Popugaeva, Vlasova and Bezprozvanny, 2015) .Action potential usually stimulate calcium ions enabling them to open voltages dependant calcium Channels (Hsu, Lane and Lin, 2018) In neurons, calcium ions acts as transmitters where they can alter the electrical conductivity by modifying the closing of sodium and potassium channels in order to stimulate the release of a neural transmitter substances(Popugaeva, Pchitskaya and Bezprozvanny, 2017) . Calcium can later lead to regulation of metabolic activities, cell growth, and long term change in synaptic efficiency thus leading to destruction of neurones (Hsu, Lane and Lin, 2018).

Calcium Ions and Alzheimer's diseaseThe Familial Alzheimer’s disease mutations in the presenilins are directly linked endoplasmic reticulum calcium ions leaked function presenilins. As a result, calcium ions dysregulation is involved in Alzheimer's disease(Small, 2009) . Various amyloid proteins have been proved to be involved in the induction of calcium ions influx into neurons, making this calcium reflux alters neurological excitability (Amidfar, Kim and Wiborg, 2018). In that case, therefore, calcium ions might be the key to the step of studying the pathogenesis of Alzheimer's disease(Popugaeva, Pchitskaya and Bezprozvanny, 2017) .

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