This document is a case study on anatomy and physiology, covering various topics such as pancreatic enzymes, blood glucose levels, ECG results, cardiovascular factors, angiotensin II, glomerular filtration rate, hormones in the uterine and ovarian cycle, atmospheric pressure, and carbon monoxide poisoning.
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Systemic Anatomy and Physiology
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Table of Contents CASE STUDY.................................................................................................................................3 References........................................................................................................................................6
CASE STUDY 1.Pancreasisanexocrineandendocrineglandbecausetheysecreteproductsinto gastrointestinal tract through a series of duct and also secrete other substances directly into the bloodstream. As an exocrine gland pancreas secrets pancreatic juice1.There are endocrine gland pancreas and these are consisting of cells which are dissolved in blood.It includes insulin which helps in lowering blood sugar level. 2.Candice was given pancreatic digestive enzymes. One digestive enzyme is also released in the stomach. What is this enzyme, what is its precursor, how is it activated, and what cells are involved? One digestive enzyme that a secreted in stomach or gastric enzyme which are also known as chief cells in its inactive from a pepsinogen which is also known as zymogen2. This is then activated in stomach by stomach acidinits active form known as pepsin. 3.Using your knowledge of how a negative feedback loop works to explain why Candice has elevated blood glucose levels Negative feedback loops include homeostatic system such as thermal regulation and blood sugar regulation3. When insulin and glucagon action on blood glucose level are mediated by two negative feedback loops where insulin act as a repressive and glucagon act as a activator. Due to failure of beta cells to secrete sufficient insulin in patients it is often seen that fluctuation in blood glucose levels arise due to which Candice has elevated blood glucose levels. 1Nieweg, O.E., Tanis, P.J. and Leong, S.P., 2020. Anatomy and Physiology of LymphaticCirculation:ApplicationtoLymphaticMapping.InAtlasof Lymphoscintigraphy and Sentinel Node Mapping(pp. 1-6). Springer, Cham. 2Kroeker,C.G.,2018.CardiovascularSystem:AnatomyandPhysiology.Cardiovascular Mechanics, pp.1-17. 3?Lakshmipathy,D.,2019.HumanAnatomyandPhysiology.InBiomedical Engineering and its Applications in Healthcare(pp. 3-42). Springer, Singapore.
4.Candice’s ECG results were normal. How does the P wave, QRS complex and T wave relate to the conduction system of the heart, Atrialdepolarisation is used by P wave for managing the ventricular depolarisation. The context of T wave consists of ventricular contraction as well as signals which are used for managing the relaxation4. 5.List the cardiovascular factors that affect blood pressure The cardio vascular factors which are affecting blood pressureto increaseincludecardiac output, volume of blood, managing the peripheral resistance of vascular musclesas well asvessel wall rigidness. Declineof blood and elasticity results within vessel walls. 6.Describe how angiotensin II controls blood pressure, and why an A2RA would reduce Candice’s blood pressure. AngiotensinIIis involved in controlling individual’sblood pressure. There are different factors likevasoconstriction, nervous stimulation andenhancement ofaldosterone biosynthesis and renal action.A2RAreduces high blood pressure by affecting angiotensin to receptor antagonist. It is also marked for reduction of stroke morbidity and mortality among patients who are facing high blood pressure levels. 7.Hypertensionhasbeenassociatedwithreducedglomerularfiltrationrate.Define glomerular filtration rate (GFR) and describe the pressures within the glomerular capsule that affect GFR. Glomeruler filtration rate refers to glomerulusflowing within body which is present in Bowman region ofkidneyand it is required for proper functioning(Lineaweaver, 2018).Capsule consists of hydrostatic pressure. There are other factors like osmotic pressure which affects membrane side and glomerular capillary increment. 8.There are four main hormones in the uterine and ovarian cycle – what are they and what is their role? Which of these are found in the combined pill (as prescribed to Candice) and how can she use the combined contraceptive pill to prevent menstruation on her climb? 4
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Thefourmainhormonesincludeluteinisinghormone,femalesexhormonesoestrogen, progesterone and follicle stimulating hormone5.The combined contraceptive pill contains hormonesprogesteroneand estrogen. 9.How does this difference in atmospheric pressure affect Candice's ability for oxygen to diffuse across into the pulmonary capillary blood from the air she breathes? There is lessoxygen pressure and it results within increasing the alveoli. This is involved in managing low blood within pulmonary capillaries. This can result within the lowering of alveoli. 10.Why did the increase in carbon monoxide lead to her death? Due to increased affinity between oxygen and hemoglobin during carbonmonooxide poisoning only little oxygen is released by tissue into the tissues6. This causes hypoxic tissue injury which can lead todeath. 5Hsu,D.W.andSuh,J.D.,2018.Anatomyandphysiologyofnasal obstruction.Otolaryngologic Clinics of North America,51(5), pp.853-865. 6Lineaweaver, W.C., 2018. Book Review: Anatomy: An Essential Textbook.
References Books and Journals Nieweg, O.E., Tanis, P.J. and Leong, S.P., 2020. Anatomy and Physiology of Lymphatic Circulation: Application to Lymphatic Mapping. InAtlas of Lymphoscintigraphy and Sentinel Node Mapping(pp. 1-6). Springer, Cham. Kroeker,C.G.,2018.CardiovascularSystem:AnatomyandPhysiology.Cardiovascular Mechanics, pp.1-17. Lakshmipathy, D., 2019. Human Anatomy and Physiology. InBiomedical Engineering and its Applications in Healthcare(pp. 3-42). Springer, Singapore. Lineaweaver, W.C., 2018. Book Review: Anatomy: An Essential Textbook. Hsu, D.W. and Suh, J.D., 2018. Anatomy and physiology of nasal obstruction.Otolaryngologic Clinics of North America,51(5), pp.853-865.