The Symptoms of Obesity Case Study

Added on -2020-02-24

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Running head: SCENARIO STUDIESScenario studiesName of the studentName of the UniversityAuthor’s note
1SCENARIO STUDIESTable of ContentsSearch items.....................................................................................................................................2Essay................................................................................................................................................2References........................................................................................................................................8
2SCENARIO STUDIESSearch itemsThe Boolean, medline and cinhal EssayThe case studies clearly indicate the symptoms of obesity. Inspite of taking various diets,she has not been able to lose weight. However, Garcinia cambogia seems to promote the weightreduction and is also used in the improvement of the lipid profile with the majority ofcompounds like hydrocitric acid and blocks the ATP citraletylase potentially inhibiting themetabolic formation of fat (Mohammadi et al, 2013). Futhermore, it has been found that theextract is able to change the adipokine levels. The main aim of the study is to analyze the effectsof Garcinia cambogia by studying the lipid profile, endocrine, calorimetric and anthropometricparameters of the obsess women. The BMI index of the women was checked taking the agebetween 25-60 years. The other things that are to be considered here are the waist hip ratio andthe fat mass percentage, resting metabolic rate, respiratory coefficients, triglycerides and the totalcholesterol that are HDL and LDL, leptin, insulin level. All of the factors are measured after thepost administration of the extract in women (Vasques et al, 2014).Obesity is the major health concern in the developing countries. Obesity is often refer tothe accumulation of body fat that results in energy imbalance that are primarily produced by thephysical inactivity, calorific intake of foods (Li et al, 2013). Excess if body fat also occurs byexcessive lipogenesis. Excess of body fact would result in other fatal diseases like dyslipidemiaand type 2 diabetes. There are other environmental factors that lead to obesity and they arerelated to the mechanisms of energy homeostasis. Leptin is an adipokine that reacts on thehypothalamus and it induces thermogenesis (Dominguez-Rodriguez, et al, 2016). The receptors
3SCENARIO STUDIESof hypothalamus are also affected by action of insulin on central nervous system. Garcinia.cambogia extract has been found to change the mode of action of these hormones that stimulatesthe very cause of pathophysiological affects of obesity and metabolic disorders. Thus the currentweight loss indicates the use of this plant extract that has been found to reduce the body weightby having the direct influence on the metabolic disorders. Thus the pharmacotherapy for treatingobesity would be supported with the use of the anorectic agents and psychostimulants. Garciniacambogia gives the natural product for the treatment of obesity by affecting both the metabolicand the nervous system profile. The major constituent of the extract is hydroxycitric acid. Thiscompound acts as the competitive inhibitor for the cytosolic enzyme, ATP-citrate and also thusprevents the endogenous lipogenic activity. HCA also stimulates the oxidation of fatty acids andimprove the lipid profile. On the other hand, is also reduces leptin and insulin levels.Interestingly, it also protects our heart from the harmful cardiovascular lipid HDL bymaintaining its optimum level. The method that the authors followed in the paper are that there were 60 women takenfrom the city of Hamburgo, Brazil. All of them found to be overweight and has the BMIapproximately equal and greater than 25. The considerations that were taken in the methodologyis that the samples were collected from the women who were on low fat diet but did not useddrugs. The study design was made with the double blind randomized study that would evaluatethe efficiency of the drug after 60 days of daily treatment with the doses of cambogia extract.The entire experiment would be standardized and would be randomly into treatment and controlgroups. The volunteers were also advised to maintain a constant level of physical activity. Themeasurements would be carried on the basis of the important weight maintenance indexes. Theevaluation was done by the anthropometric measurements, resting energy expenditure, lipid

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