This article discusses the management of type 1 diabetes and diabetic ketoacidosis, including the pathophysiology, nursing interventions, and medication management. It provides insights into the importance of fluid and electrolyte replacement, insulin therapy, and lifestyle changes for better symptom management.
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Running head: TYPE 1 DIABETES MANAGEMENT TYPE 1 DIABETES MANAGEMENT Name of the student: Name of the university: Author note:
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1 TYPE 1 DIABETES MANAGEMENT Introduction: Type-1 Diabetes can be described as an auto-immune disorder which takes place when the immune system of the body attacks and destroys its owninsulin-producing beta cells present in the pancreas (Danne et al., 2019). Diabetic ketoacidosis (DKA) might also follow when the symptoms of type-1 diabetes is not managed successfully. The present case study show a patient named Bill suffering from type-1 diabetes along with (DKA). This assignment would show how nursing professionals can undertake proper interventions, strategies and medication management to help the patient overcome the disorders successfully. Pathophysiology of type 1 diabetes and diabetic ketoacidosis: Type 1 diabetes can be described as the culmination of the two actions – lymphocytic infiltration as well as destruction of the insulin secreting cells beta cells of the islets of Langerhans in the pancreatic region. Researchers are of the opinion that when beta cell mass that are responsible for secreting insulin gets decreased, insulin secretion also falls down below the required level. This occurrence takes place until the available insulin is no longer found to be appropriate for maintaining normal blood glucose levels (Farsani et al., 2017). The condition of hyperglycemia results when almost about 80 to 90% of the beta cells undergo destruction. In such situations, patients are seen to require exogenous insulin for reversing the catabolic conditions as well as prevention of the ketosis and even for the decrease of the hyperglycemia along with normalization of lipid and protein metabolism.This disorder is actually a chronic autoimmune disorder which is seen to take place in mainly genetically susceptible individuals which might be precipitated by the number of environmental factors. Studies are of the opinion that in susceptible individuals, the immune system gets triggered to develop an auto-immune
2 TYPE 1 DIABETES MANAGEMENT response against that of the altered pancreatic beta cell antigens or the molecule in the beta cells which resemble to that of the viral proteins. It has been found that about 85% of the affected patients have exhibited circulating islets cell antibodies. It has been found that the majority numbers of affected individuals are also found to have detectable anti-insulin antibodies.Burns et al. (2018) had clearly stated that most of these islet cells antibodies are seen to get directed against that of the glutamic acid decarboxylase (GAD) within pancreatic beta cells.Another model had been also put forward by many studies. It states that environmental triggers can result in inducing islet autoimmunity and beta-cell death in the different susceptible and vulnerable individuals. This actually results in initiating a series of pre-diabetic stages that ultimately sets forth the clinical onset of that of the disorder. Diabetic ketoacidosis can be described as the life-threatening problem that can affect people with diabetes. This situation is seen to take place when the body starts to break own fat at a rate that is much faster. The liver in this situation is seen to process the fat in ways that it gets turned to fuel called the ketones that ultimately make the blood acidic in nature (Duca et al., 2017). This situation is mainly seen to happen when signal from that of the insulin in the body becomes so low that glucose cannot get into the cells to be used as the fuel source, when the liver makes huge amount of the blood sugar level and when the fat gets broken down much faster than for the body to process. It is seen that these fat gets broken down in the liver into the fuels and this is often called ketones which are actually produced when the body breaks down fat after a longer period of time between the meals (Peters et al., 2016). It has been found that when ketones are produced quickly and are built up in the blood as well as the urine, they can be found to become toxic by making the blood acidic. Researchers have termed this condition is known to be ketoacidosis.
3 TYPE 1 DIABETES MANAGEMENT Tachypnea or deep, rapid breathing is one of the symptom of DKA which was also observed in the patient called Bill.It has been found that when the body is seen to produce or ingest a much higher amount of acid or when the kidneys and lings are seen to fail, blood acid levels rises. In cases of type-1 diabetes, ketones become higher in amount in the blood resulting in the increase of the blood acid level. When the blood is seen to become too acidic, acidosis is seen to take place and therefore, the body tries its best in restoring the imbalance (Robinson et al., 2016). The body tries to take deeper as well as longer breaths where the lungs try to expel more acidic carbon disoxide than that of the normal. Hence, rapid breathing s seen in this disorder often called the Kussmaul breathing which was also observed in Bill. Another symptom is the fruity smell in the breath of the patient which was also observed in Bill which comprised of acetone smell in the breath. As the lungs try to expel more acetone-containing carbon dioxide, the smell of his breath can also be found to be fruity. Another symptom that is also observed is the flushed face which was also observed in Bill. Decrease in alertness and increase of confusion is another symptom that was also observed when patient named Bill was admitted. This can be contributed to a number of reasons (Gard et al., 2017). Because of the increased concentration of the acids in the blood from that of the breakdown of the fats, the body is seen to urinate in excess for removing these compounds from that of the blood. Excessive of the urination in the setting of the continuous production of the keto acids can result in dehydration resulting in a general feeling of illness, fatigue. Headache and slowed mental capacity. Excessive urination can also result in huge loss of the potassium causing symptoms of nauseas and vomiting, fainting and drowsiness, muscle cramps and others which were also seen in the patient (Semenkovich et al., 2019).
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4 TYPE 1 DIABETES MANAGEMENT Nursing and medication management: In order to manage diabetes ketoacidosis, the nurses need to undertake interventions so as to help the patient named bill get over the symptoms. The first intervention would be fluid replacement where the patient would be provided fluids either by the mouth or by the vein in an intravenous manner unless they become rehydrated. The main rationale of doing so is that the fluids would replace those which have been lost though excessive urination as well as also help in diluting the excess sugar present in the blood (Henry et al., 2015). The second intervention that the nurse should be undertaking is the electrolyte replacement. Studies are of the opinion that electrolytes are mainly the minerals in the blood that can carry an electric charge like that of sodium, potassium as well as chloride. It has been found that the absence of insulin can help in lowering the level of electrolytes in the blood. The patient named Bill would be given the electrolytes through a vein (Lennerz et al., 2018). This would help in keeping the heart muscles as well as the nerve cells and the muscles function properly. Another intervention is the insulin therapy. Insulin would mainly help in reversing the process that causes diabetic ketoacidosis. In addition to that of the fluids as well as the electrolytes, the nurses should provide Bill with insulin therapy that would be mainly given though the vein. When the blood sugar level would fall to about 200mg/dL or below 11.1 mmol/L and the blood of the patient is no longer acidic, the nursing professionals can stop the intravenous insulin therapy and thereby initiate the normal subcutaneous therapy. Studies are of the opinion that having type-1 diabetes would require significant lifestyle change for better maintenance of the symptoms and to avoid any form of threatening situations (Nyenwe t al., 2016). People with that of diabetes type1should be educated about a number of aspects like frequent testing of the blood sugar levels as well as initiate careful
5 TYPE 1 DIABETES MANAGEMENT meal planning after consultation with the dietician. Bill should be also advised to undertake daily exercises and take insulin and other medications in a disciplined manner to avoid any form of threatening conditions in the body. Medication management: In order to treat diabetic ketoacidosis, the medication that can be provided is the short- acting insulin which would help in correcting the hyperglycemia in case of DKA. Studies are of the opinion that rapid acting insulin mainly helps by suppressing the hepatic glucose output thereby enhancing glucose uptake by the peripheral tissues (Foster et al., 2019). This insulin can also seen to be suppressing the ketogenesis as well as lipolysis thereby helping n the stimulation of the proper use of glucose by the different cells along with the reduction of the blood sugar levels. Studies are of the opinion that rapid acting insulin mainly help in the correction of hyperglycemia. The normal blood glucose level should be 7.8 mmol/L but it has been found to be quite high for about 38.5 which show treatment of short acting insulin is important for the patient to tackle hyperglycemia (Bergenstal et al., 2016). The nurse can use the insulin namely Aspart also called Novolog which is found to be helpful in Glycemic control in the adults. For type 1 diabetes, professionals might administer 0.2-0.6 unit/kg/day in the form of divided doses. Studies are of the opinion that conservative doses of that of 0.2-0.4 unit/kg/day are advised to be followed for reduction of the risk of hypoglycemia. This medication might come as a solution or as a suspension and can be injected subcutaneously. It should be injected about 5 to 10 minutes before the meal (Umpierrez et al., 2016). The suspension is used for treating type-1 diabetes and should be injected for 15 minutes before meal. The nurses need to be careful about changes in the blood sugar level and might cause side effects like the redness or swelling as well as itching found to be occurring at the site of injection, along with various changes in the feel of the skin,
6 TYPE 1 DIABETES MANAGEMENT thickening of skin, constipation and weight gain. Nurses should monitor these signs and immediately take interventions if they occur. The next set of medication that should be also advised for the patient would be long acting insulin which can be used in combination with that of the rapid acting insulin. This mainly helps in lowering the blood glucose levels when the rapid acting insulin would stop working. It should be taken once or twice a day. Isophaneis actually human-made insulin which lowers the amount of sugar in the blood. It is seen to start working after 30 minutes and can be found to be working for as long as the 12 to 24 hours. This medication is mainly used as an injection provided under the skin. Some of the side effects that might be seen to result from this medication is allergic reactions like skin rash, breathing problems and others, itching, burning as well as swelling or rash at the site where the patients are injected (Umpierrez et al., 2016). There might be also increase as well as decrease in the fatty tissue that are present under the skin because of the overuse of particular injection site. This insulin us seen to provide basal requirement of a basal-bolus regimen called the Multiple Daily Insulin (MDI) injections where 3 to 4 insulin injections per day are provided with combination of long acting and rapid acting insulin. It may act with medications like clonidine, reserpine, albuterol and other and hence, nurse should be very careful while administering the medication to the patient. Another medication that can be also suggested for the patient is called the Pramlintide. This is an inject-able drug which actually results in lowering the level of sugar in the blood. This medication is a synthetic hormone that is found to resemble similar to human amylin. This si a hormone that is produced from the pancreas and then gets released in the blood after meals. This hormone actually helps the body in regulation of glucose level in the blood. Amylin is found to work in several ways for controlling blood glucose like slowing the rate at which good is
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7 TYPE 1 DIABETES MANAGEMENT absorbed from the intestine. It also helps in the reduction of the production of the glucose by the liver by inhibition of the action of glucagon which is a hormone that causes stimulation of the production of glucose by the liver (Goldenberg et al., 2016). Amylin also causes reduction in the appetite. In different studies, pramline-treated patients are seen to achieve lower blood glucose level and experienced weight loss. This medication can be also prescribed for Bill to control his blood glucose levels successfully. The nursing professional should initiate this medication by the dosage of 15 mcg SC immediately before major meals and should increase it by 15 mcg q3Days. Some of the side effects that the nurse should consider and monitor in the patient when treated with this medication are the nausea, hypoglycemia, headache, weight loss and headache and fatigue (Henriksson et al., 2016). Nurse should undertake proper precautionary measure when administering the medication Conclusion: From the above discussion, it can be seen that people suffering from type-1 diabetes like Bill can suffer from worsening health conditions if the glucose level in the blood is not managed successfully within the safe limits. Destruction of the beta cells results in prevention of the release of insulin that causes increase in blood glucose level and affecting the health condition of the patient. Diabetic ketoacidosis might also take place when acid level in the blood increases. Nursing professionals would need to ensure providing the right interventions like fluid balance, electrolyte balance and insulin therapies to help patient overcome DKA. They also need to initiate rapid acting and long acting insulin followed by pramline to ensure safety of the patient helping him to live better quality life.
8 TYPE 1 DIABETES MANAGEMENT References: Bergenstal, R. M., Garg, S., Weinzimer, S. A., Buckingham, B. A., Bode, B. W., Tamborlane, W. V., & Kaufman, F. R. (2016). Safety of a hybrid closed-loop insulin delivery system in patients with type 1 diabetes.Jama,316(13), 1407-1408. Burns, K., Farrell, K., Myszka, R., Park, K., & Holmes‐Walker, D. J. (2018). Access to a youth‐ specific service for young adults with type 1 diabetes mellitus is associated with decreasedhospitallengthofstayfordiabeticketoacidosis.Internalmedicine journal,48(4), 396-402. Danne, T., Garg, S., Peters, A. L., Buse, J. B., Mathieu, C., Pettus, J. H., ... & Cariou, B. (2019). International Consensus on Risk Management of Diabetic Ketoacidosis in Patients with Type1DiabetesTreatedwithSodium-GlucoseCotransporter(SGLT) Inhibitors.Diabetes care. Duca, L. M., Wang, B., Rewers, M., & Rewers, A. (2017). Diabetic ketoacidosis at diagnosis of type 1 diabetes predicts poor long-term glycemic control.Diabetes Care,40(9), 1249- 1255. Farsani, S. F., Brodovicz, K., Soleymanlou, N., Marquard, J., Wissinger, E., & Maiese, B. A. (2017). Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review.BMJ open,7(7), e016587. Foster, N. C., Beck, R. W., Miller, K. M., Clements, M. A., Rickels, M. R., DiMeglio, L. A., ... & Olson, B. A. (2019). State of type 1 diabetes management and outcomes from the T1D Exchange in 2016–2018.Diabetes technology & therapeutics,21(2), 66-72.
9 TYPE 1 DIABETES MANAGEMENT Garg, S. K., Henry, R. R., Banks, P., Buse, J. B., Davies, M. J., Fulcher, G. R., ... & Danne, T. (2017). Effects of sotagliflozin added to insulin in patients with type 1 diabetes.New England Journal of Medicine,377(24), 2337-2348. Goldenberg, R. M., Berard, L. D., Cheng, A. Y., Gilbert, J. D., Verma, S., Woo, V. C., & Yale, J. F.(2016).SGLT2inhibitor–associateddiabeticketoacidosis:clinicalreviewand recommendations for prevention and diagnosis.Clinical Therapeutics,38(12), 2654- 2664. Henriksson, M., Jindal, R., Sternhufvud, C., Bergenheim, K., Sörstadius, E., & Willis, M. (2016).Asystematicreviewofcost-effectivenessmodelsintype1diabetes mellitus.Pharmacoeconomics,34(6), 569-585. Henry, R. R., Thakkar, P., Tong, C., Polidori, D., & Alba, M. (2015). Efficacy and safety of canagliflozin, a sodium–glucose cotransporter 2 inhibitor, as add-on to insulin in patients with type 1 diabetes.Diabetes Care,38(12), 2258-2265. Lennerz, B. S., Barton, A., Bernstein, R. K., Dikeman, R. D., Diulus, C., Hallberg, S., ... & Ludwig, D. S. (2018). Management of type 1 diabetes with a very low–carbohydrate diet.Pediatrics,141(6), e20173349. Nyenwe, E. A., & Kitabchi, A. E. (2016). The evolution of diabetic ketoacidosis: an update of its etiology, pathogenesis and management.Metabolism,65(4), 507-521. Peters, A. L., Henry, R. R., Thakkar, P., Tong, C., & Alba, M. (2016). Diabetic ketoacidosis with canagliflozin,asodium–glucosecotransporter2inhibitor,inpatientswithtype1 diabetes.Diabetes Care,39(4), 532-538.
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10 TYPE 1 DIABETES MANAGEMENT Robinson, C., Cochran, E., Gorden, P., & Brown, R. J. (2016). Management of Diabetic Ketoacidosis in Severe Insulin Resistance.Diabetes care,39(8), e116-e118. Semenkovich, K., Berlin, K. S., Ankney, R. L., Klages, K. L., Keenan, M. E., Rybak, T. M., ... & Eddington,A.(2019).Predictorsofdiabeticketoacidosishospitalizationsand hemoglobin A1c among youth with Type 1 diabetes.Health Psychology. Umpierrez,G.,&Korytkowski,M.(2016).Diabeticemergencies—ketoacidosis, hyperglycaemichyperosmolarstateandhypoglycaemia.Naturereviews Endocrinology,12(4), 222.