This presentation discusses the challenges faced by healthcare workers while working with patients with co-existing substance use and mental health issues. It also focuses on the ways of addressing all the challenges and the methods of overcoming them. The challenges include accurate diagnosis, ethical issues, and convincing patients about the need for awareness. The methods of overcoming these challenges include counseling, social support intervention, awareness campaigns, and an empathetic attitude towards patients. The presentation also includes a literature review on the prevalence of substance use disorders and mental health issues among patients.