logo

Anti-integrin therapy to dampen inflammation and reduce scar formation?

   

Added on  2020-03-04

8 Pages1691 Words415 Views
Running head: IMMUNITY AND DISEASE Immunity and DiseaseName of the student:Name of the university:Authors note:
Anti-integrin therapy to dampen inflammation and reduce scar formation?_1
1IMMUNITY AND DISEASEProposal #1 Anti-integrin therapy to dampen inflammation and reduce scar formation? Project Background Anti- integrin therapy is being widely used by the scientists and the researcherspresently. It is being used in treating several types of diseases such as cancer and help in thesurvival of human beings. Integrin proteins expressed on both endothelial and tumor cells andhence it helps in mainly three activities such as antiangiogenesis; anti-invasion; and anti-tumor.Anti- integrin therapy is also used in curing individuals suffering from including multiplesclerosis, inflammatory bowel disease, and psoriasis.Alpha4beta1 (very late antigen-4) andalphaLbeta2 (leucocyte function-associated antigen-1) integrins have important roles in otherimmune processes such as including the formation of the immune synapse and the differentiationof T helper 1 lymphocytes.It is very painful for the individuals who suffer from scarring inexcess that results from resultingfrom burns, scalds and several other injuries.It leads to bothphysically and psychological effects in them.Presently we do not have any licensed drugs thatprevent or reduce the formation of scar.Inflammation plays a significant role in the normal ofwound healing process.It has been observed that it does not require infection to occur. But if theinflammation is prolonged, it does not lead to the healing of wound(Mosli, Rivera-Nieves andFeagan 2014).Inflammation in excessplays a significant role in the formation of scar in whichthe level of inflammation in an acute wound will determine the extent to which fibrosis andscarring would occur.It has been observed through several research experiments that unfavourable effects ofrepair in the tissues including fibrosis and the formation of scar occurs due inflammation that is
Anti-integrin therapy to dampen inflammation and reduce scar formation?_2
2IMMUNITY AND DISEASEassociated with macrophages. According to the experiments, wounds that do not have or havelow numbers of macrophages have experienced reduced fibrosis and scarring as compared towild-type mice.Targeted depletion of macrophages during the early inflammatory stage (days 0-5) of healingresulted in scarring to a minimum level in a mouse model.According to theseresults it can be suggested that reducing the numbers of macrophages and early inflammation(day 2-5) could potentially reduce the formation of scars. Macrophages are immune cells that play a significant role in regulating the formation ofscars. They enter the wound as a monocyte 2 days after the injury occurs.There are a fewproteins known as surface integrins that play an important role for the migration of monocytesinto sites of inflammation and injury. Integrins are adhesion receptors and consist of twosubunits, that help in mediating the cell-cell and cell-matrix interactions. These interactions areimportant for the adhesion and migration of the cell. There are different types of integrins andare expressed in a different manner. Integrins such as αDβ2, αMβ2, αXβto, αLβ2 and αEβ7 arespecific two leukocytes. Integrins act as excellent therapeutic targets since their ligand-binding domain is exposedto the extracellular milieu and they can be inhibited through pharmacological means.There arecertain diseases which can be treated in an effective manner by using licensed anti-integrintherapies that target integrins that are specific to immunity. They are used effectively in clinicalsettings to treat diseases in which inflammation plays a significant role in the progression ofdisease.As the inflammatory processes play a crucial role in the healing of woundsand anti-integrin therapies have been successful in reducing inflammation in other diseases, it is proposedthat anti-integrin therapy will reduce inflammation and thus improve the formation of scars.
Anti-integrin therapy to dampen inflammation and reduce scar formation?_3

End of preview

Want to access all the pages? Upload your documents or become a member.

Related Documents
Experimental Study - Leukocyte Specific Integrins In Scar Healing
|11
|2253
|181

Plasma Rich Protein and its Effects on Wound Healing - Nursing Assignment
|5
|1136
|142

Nursing Assignment on Wound Care
|11
|2924
|95

Anatomy Case Study 2022
|9
|2047
|45

Stress and the Immune Response
|5
|1098
|460

Answer about Healthcare 2022
|8
|2059
|20