Case Study on medicines Assignment PDF
Added on 2021-02-19
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Case Study
Table of ContentsINTRODUCTION...........................................................................................................................1MAIN BODY..................................................................................................................................1PART A...........................................................................................................................................11. Pathophysiology and aetiology and manifestations of Osteoarthritis......................................12. Paracetamol and Panadol Tablets............................................................................................23. Voltaren Rapid and its use in Osteoarthritis............................................................................24. Safety Consideration for NSAIDs...........................................................................................35. Negative and Positive interactions between the medications and herbal or nutritionalformulas.......................................................................................................................................3PART B...........................................................................................................................................46) Use of corticosteroids in inflammatory joint disease..............................................................47) Explain 3 CNS drugs and adverse effects...............................................................................48) Discussion on altered pharmacokinetics in elderly.................................................................59) Drug monograph completed. (Appendix)...............................................................................510) Literature review of chosen drugs.........................................................................................5CONCLUSION................................................................................................................................6REFERENCES................................................................................................................................7APPENDIX......................................................................................................................................7
INTRODUCTIONOsteoarthritis is an extreme level of arthritis and can impact a person both physically andemotionally. In this report, the case study of Mrs F. has been discussed where in scenario one,she is suffering from chronic moderate osteoarthritis and in scenario two, the osteoarthritis hasbecome more severe. This report will also highlight the various medicines that are being taken byMrs F. and they have been evaluated and a literature review has been conducted on the chosendrugs in order to analyse the pharmacological treatment of Mrs F. in a better manner.MAIN BODYPART A1. Pathophysiology and aetiology and manifestations of OsteoarthritisAs per the view of Ackerman, Bohensky, Zomer, Tacey, Gorelik, Brand and De Steiger,(2019), it is normal to experience wear and tear in the cartilage surrounding the joints with thepassing age. In order to balance degradative enzymes in the cartilage formulation with that ofsynthetic enzymes in the body, it is essential that tissue inhibitors are regulated. Ackerman andet.al., (2019), has further stated that the major development in osteoarthritis pathophysiology isrecognizing the role that inflammatory cytokines has played and release of mediators likesynovial tissue which cause disruption in the balance. The author has also detailed theendogenous and extrogenous factors that help in pathophysiological treatment of osteoarthritis. The aetiology of the osteoarthritis can be traced back to Chondropenia which is the firststage at which a person continuously loses the cartilage and can even be termed as anintermediate stage when the initial stage in continuum i.e. loss of cartilage due to a chronic injuryand this process of cartilage loss culminates at the last stage which is osteoarthritis (Ackermanand et.al., 2019). There are many research papers that have supported the fact that a major kneeinjury ultimately leads to loss of cartilage i.e. osteoarthritis. Author, Zhu, Chang, Wang, Lu,Han, Zheng, Meng, Wu, Jiang, Hannon and Hunter (2018), has researched that even a smalldegree of misalignment can lead to increased pressure within a knee joint and this ultimatelyleads to Chondropenia paving way for Osteoarthritis. Author has further stated that obesity is amajor contributor in osteoarthritis and Gap Junctions is another contributor in formulation ofcartilage degrading tissue.1
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